Evolution of New Genotype of West Nile Virus in North America

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  McMullen, Allison R. ; May, Fiona J. ; Li, Li ; Guzman, Hilda ; Bueno, Rudy ; Dennett, James A. ; Tesh, Robert B. ; Barrett, Alan D.T.
• Description:
  Previous studies of North American isolates of West Nile virus (WNV) during 1999-2005 suggested that the virus had reached genetic homeostasis in North America. However, genomic sequencing of WNV isolates from Harris County, Texas, during 2002-2009 suggests that this is not the case. Three new genetic groups have been identified in Texas since 2005. Spread of the southwestern US genotype (SW/WN03) from the Arizona/Colorado/northern Mexico region to California, Illinois, New Mexico, New York, North Dakota, and the Texas Gulf Coast demonstrates continued evolution of WNV. Thus, WNV continues to evolve in North America, as demonstrated by selection of this new genotype. Continued surveillance of the virus is essential as it continues to evolve in the New World.
• Subjects:
  Amino Acid Substitution Animals Cercopithecus Aethiops Evolution, Molecular Genetic Variation Genotype Phylogeny Research RNA, Viral Selection, Genetic Vero Cells West Nile Fever

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• Source:
  Emerg Infect Dis. 17(5):785-793.
• Document Type:
  Journal Article
• Funding:
  AI 067847/AI/NIAID NIH HHS/United States ; AI 07526/AI/NIAID NIH HHS/United States ; N01-AI25489/AI/NIAID NIH HHS/United States ; N01-AI30027/AI/NIAID NIH HHS/United States
• Place as Subject:
  North America
• Location:
  North America
• Volume:
  17
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:652025f0ceac6c1666c01464b5950b070fb30132f4d8ccc00842d954415bc733
• Download URL:
  https://stacks.cdc.gov/view/cdc/24373/cdc_24373_DS1.pdf
• File Type:
  [PDF - 496.56 KB ]