Suppression of silica-induced toxicity with organosilane surface coating.

Details

• Personal Author:
  Castranova, Vincent ; Dalal NS ; Dyke K ; Vallyathan V ; Wu L
• Description:
  The possibility of reducing the cytotoxicity of crystalline silica (14808607) through the use of an organosilane surface coating was considered. Theories which have been proposed to account for the cytotoxicity of crystalline silica were reviewed. In each of the theories discussed, surface properties were important in the cytotoxicity of silica. It was proposed that the application of an organosilane material to the surface of silica particles would decrease their ability to cause lung disease. In addition to preventing the cytotoxic effects of silica, organosilane coating also would effectively decrease the ability of silica particles to activate oxidant production by alveolar macrophages. Prosil-28, an organosilane commonly used to silicanize laboratory glassware, was used to coat silica, and the coated silica was used in in-vitro and in-vivo studies. Studies indicated that coated silica is significantly less inflammatory and fibrotic, as determined by measuring lung weight and hydroxyproline content, respectively. The authors suggest that further studies examine whether it is possible to incorporate organosilane coating agents into water sprays of drill bits or rock grinders, thus coating silica particles as they are generated, and determine if such treatment would decrease the pathogenic potential of silica dust. [Description provided by NIOSH]
• Subjects:
  Dust Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide
• Keywords:
  Silica-dusts; Mineral-dusts; Respiratory-system-disorders; Lung-irritants; Alveolar-cells; In-vitro-studies; In-vivo-studies; Coatings; Protective-coatings
• ISBN:
  9780849347092
• Publisher:
  CRC Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  283-291
• NIOSHTIC Number:
  nn:00238733
• Citation:
  Silica and silica-induced lung diseases. Castranova V, Vallyathan V, Wallace WE, eds. Boca Raton, FL: CRC Press, 1995 Dec; :283-291
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Editor(s):
  Castranova V; Vallyathan V; Wallace WE
• Federal Fiscal Year:
  1996
• Peer Reviewed:
  False
• Source Full Name:
  Silica and silica-induced lung diseases
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243613/cdc_243613_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]