Epidemiology, molecular.

Details

• Personal Author:
  Perera FP ; Rothman N ; Schulte, Paul A.
• Description:
  The use of molecular biological methods in molecular epidemiology (ME) as a powerful tool for public health researchers was reviewed. ME used the enhanced resolving power of molecular biology to assess exposure/disease relationships. ME identified biological markers that indicated exposure to xenobiotic agents; revealed a biological effect early in the course of disease; or represented unique disease subtypes to the development of disease. ME compared populations with respect to dose of an environmental agent as measured by critical macromolecules, such as DNA. ME used a validated biological marker of effect instead of frank disease outcome. Biological markers intermediate between exposure and disease were used to screen people or allowed for early disease detection. ME discerned the role of host factors, particularly genetics, in accounting for variations in response. In applied studies, the biomarker did not predict an increased risk of disease, but provided insight into the association of exposure and biologic processes. Developmental studies addressed questions about the presence of newly developed markers in the population. The authors conclude that the use of molecular biomarkers in public health practice is still in its infancy, and several promising markers may soon find their way into the public health arena. [Description provided by NIOSH]
• Subjects:
  DNA Environmental Exposure Epidemiology Genetics Occupational Exposure Occupational Health Safety
• Keywords:
  Humans; Biological-monitoring; Epidemiology; Molecular-biology; DNA-adducts; DNA-damage; Environmental-exposure; Occupational-exposure; Genetic-disorders
• ISBN:
  9783527284788
• Publisher:
  VCH Publishers, Inc.
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  New York ; Ohio ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  258-262
• Volume:
  2
• NIOSHTIC Number:
  nn:00238642
• Citation:
  Encyclopedia of molecular biology and molecular medicine: denaturation of DNA to growth factors, volume 2. Meyers RA, ed. Weinheim [u.a.]: VCH Publishers, Inc., 1996 Apr; 2:258-262
• Editor(s):
  Meyers RA
• Federal Fiscal Year:
  1996
• Peer Reviewed:
  False
• Source Full Name:
  Encyclopedia of molecular biology and molecular medicine: denaturation of DNA to growth factors, volume 2
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243606/cdc_243606_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]