Genotypic Profile of Streptococcus suis Serotype 2 and Clinical Features of Infection in Humans, Thailand

Kerdsin, Anusak; Dejsirilert, Surang; Puangpatra, Parichart; Sripakdee, Saowalak; Chumla, Koranan; Boonkerd, Nitsara; Polwichai, Pitimol; Tanimura, Susumu; Takeuchi, Dan; Nakayama, Tatsuya; Nakamura, Shota; Akeda, Yukihiro; Gottschalk, Marcelo; Sawanpanyalert, Pathom; Oishi, Kazunori

doi:10.3201/eid1705.100754

i

Genotypic Profile of Streptococcus suis Serotype 2 and Clinical Features of Infection in Humans, Thailand

Supporting Files Public Domain

May 2011
By Kerdsin, Anusak ; Dejsirilert, Surang ; Puangpatra, Parichart ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Kerdsin, Anusak ; Dejsirilert, Surang ; Puangpatra, Parichart ; Sripakdee, Saowalak ; Chumla, Koranan ; Boonkerd, Nitsara ; Polwichai, Pitimol ; Tanimura, Susumu ; Takeuchi, Dan ; Nakayama, Tatsuya ; Nakamura, Shota ; Akeda, Yukihiro ; Gottschalk, Marcelo ; Sawanpanyalert, Pathom ; Oishi, Kazunori
Description:

To examine associations between clinical features of Streptococcus suis serotype 2 infections in humans in Thailand and genotypic profiles of isolates, we conducted a retrospective study during 2006-2008. Of 165 patients for whom bacterial cultures of blood, cerebrospinal fluid, or both were positive for S. suis serotype 2, the major multilocus sequence types (STs) found were ST1 (62.4%) and ST104 (25.5%); the latter is unique to Thailand. Clinical features were examined for 158 patients. Infections were sporadic; case-fatality rate for adults was 9.5%, primarily in northern Thailand. Disease incidence peaked during the rainy season. Disease was classified as meningitis (58.9%) or nonmeningitis (41.1%, and included sepsis [35.4%] and others [5.7%]). Although ST1 strains were significantly associated with the meningitis category (p<0.0001), ST104 strains were significantly associated with the nonmeningitis category (p<0.0001). The ST1 and ST104 strains are capable of causing sepsis, but only the ST1 strains commonly cause meningitis.
Subjects:

Adolescent Adult Aged Aged, 80 And Over Cluster Analysis Female Genotype Humans Male Middle Aged Molecular Epidemiology Multilocus Sequence Typing Phylogeography Retrospective Studies Seasons Streptococcal Infections Young Adult
Source:

Emerg Infect Dis. 17(5):835-842.
Document Type:

Journal Article
Place as Subject:

Thailand
Location:

Asia
Volume:

17
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:ec83c920ef994865ed38728fa0c5db93f2f4df31a11b4f8bf7cbeb4b32564019
Download URL:

https://stacks.cdc.gov/view/cdc/24344/cdc_24344_DS1.pdf
File Type:

[PDF - 452.89 KB ]

File Language:

English

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