A model for staging asbestos-related lung effects after cessation of exposure based on clinical demographic and bronchoscopic data.

Details

• Personal Author:
  Cullen MR ; Marenberg ME ; Merrill WW
• Description:
  A model for the identification of factors predisposing asbestos (1332214) exposed workers to the development of fibrosis versus lung cancer was described. Patients previously identified with pulmonary asbestosis or asbestos related nonmalignant pleural disease were interviewed about their asbestos exposures and smoking and dietary histories and underwent a series of clinical procedures. Subjects were divided into four groups based on clinical findings and neutrophil concentrations in bronchoalveolar lavage (BAL) fluid. The first group demonstrated minimal radiographic changes, few BAL neutrophils, moderate functional changes, and rare airway metaplasia. The second group had minimal radiographic changes, higher BAL neutrophil levels, greater physiological alterations, and metaplasia in about half of the cases. Radiographic and functional evidence of asbestosis were seen in group three with little or no metaplasia, functional changes, or increased BAL neutrophils while the fourth group had high BAL neutrophil levels, a high rate of metaplasia, and progressive loss of function. Markedly higher rates of smoking and airway obstruction were seen in subjects in the fourth group compared with the third group and younger subjects tended to have higher BAL neutrophil levels compared with older subjects. The authors conclude that these results suggest that the progression of disease activity among asbestos exposed workers may be related to smoking, airway obstruction, age, and degree of metaplasia. [Description provided by NIOSH]
• Subjects:
  Age Factors Asbestos Inorganic Chemicals Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smokers Tobacco Products

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• Keywords:
  NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Asbestos-workers; Lung-disease; Lung-cancer; Lung-fibrosis; Physiological-effects; Risk-factors; Cigarette-smoking; Age-factors
• ISBN:
  9780911131505
• ISSN:
  0276-5063
• Publisher:
  Princeton Scientific Publishing Co., Inc.
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  287-303
• NIOSHTIC Number:
  nn:00224023
• Citation:
  The identification and control of environmental and occupational diseases: asbestos and cancers. Upton A, Mehlman MA, eds. Princton, NJ; Princeton Scientific Publishing Co., Inc., Advances in Modern Environmental Toxicology, 1994 Jan; :287-303
• Contact Point Address:
  Internal Medicine Yale University School of Med 109-Lci, P O Box 3333 New Haven, CT 06520
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4)
• Editor(s):
  Upton A; Mehlman MA
• Federal Fiscal Year:
  1994
• Performing Organization:
  Yale University, New Haven, Connecticut
• Peer Reviewed:
  True
• Start Date:
  19860101
• Source Full Name:
  The identification and control of environmental and occupational diseases: asbestos and cancers. Upton A, Mehlman MA, eds. Princton, NJ; Princeton Scientific Publishing Co., Inc., Advances in Modern Environmental Toxicology
• End Date:
  19931231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243342/cdc_243342_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]