Epithelial surface proteins: markers of cancer risk.

Details

• Personal Author:
  Carter D ; Cullen MR ; Gee JB ; Horwitz R ; Matthay RA ; Merrill WW
• Description:
  The relationship between proteins synthesized by airway mucosal cells and the presence of metaplasia detectable in biopsies of the bronchial mucosa was determined. Bronchoalveolar lavage and airway biopsies were performed on 50 subjects who had a history of occupational exposure to asbestos (1332214). All but eight of the subjects were current or former smokers. Metaplasia seen in mucosal biopsies and change in diffusion capacity for carbon-monoxide (CO) were used as surrogates for cancer risk and pulmonary fibrosis respectively. A third of the subjects showed keratinizing metaplasia, however, keratinizing metaplasia could not be related to levels of free secretory component or the keratins in lavage fluid. Cigarette smoking and the number of acute inflammatory cells were related to keratinizing metaplasia; nonsmokers had the lowest frequency of metaplasia, and current smokers had the highest frequency. When diffusion capacity was used as a surrogate for functional deterioration, acute inflammatory cells were statistically related to the rate of lung functional loss over time. Other occupational and demographic factors were not found to be significantly associated with metaplasia or functional deterioration. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Asbestos Inorganic Chemicals Lung Lung Diseases Neoplasms Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Safety Smokers Tobacco Products

  More +
• Keywords:
  NIOSH-Grant; Respiratory-system-disorders; Occupational-exposure; Asbestos-fibers; Asbestos-workers; Humans; Cigarette-smoking; Risk-analysis; Lung-function; Lung-cancer
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-51
• NIOSHTIC Number:
  nn:00201448
• NTIS Accession Number:
  PB92115674
• Citation:
  Yale University School of Medicine, New Haven, Connecticut 1991 Feb; :-51
• Contact Point Address:
  Internal Medicine Yale University School of Med 109-Lci, P O Box 3333 New Haven, CT 06520
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4)
• Federal Fiscal Year:
  1991
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Performing Organization:
  Yale University, New Haven, Connecticut
• Peer Reviewed:
  False
• Start Date:
  19860101
• Source Full Name:
  Yale University School of Medicine, New Haven, Connecticut
• End Date:
  19931231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246232/cdc_246232_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]