NIOSH Testimony on a Cross-Species Scaling Factor for Carcinogen Risk Assessment Based on Equivalence of mg/kg3/4/Day by R. W. Niemeier, August 4, 1992.

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  This testimony summarized information and comments from NIOSH regarding the proposal for a unified animal to human scaling factor for carcinogen risk assessment. A scaling factor of body weight raised to the 3/4 power had been proposed. This factor would be adopted by the Environmental Protection Agency, the Food and Drug Administration, and the Consumer Product Safety Commission. The assumptions under which the scaling factor was established were discussed. The graphs contained in the draft report to illustrate the cross species scaling relationships should be labeled as theoretically expected relationships. Although the draft report made it very clear that case specific information is considered preferable to the use of the default scaling factor and that the development of case specific information is encouraged, the question of just how the case specific information should be used when it is available was left open. The question of pharmacodynamic differences between species in susceptibility to carcinogens was considered. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no PDF
• Subjects:
  Carcinogens Laboratories Occupational Health Risk Assessment Safety
• Keywords:
  NIOSH-Author; NIOSH-Testimony; Niemeier-R-W; Risk-analysis; Carcinogens; Laboratory-animals; Carcinogenesis; Comparative-toxicology;
• Document Type:
  Text
• Genre:
  Testimony
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSDTT - Division of Standards Development and Technology Transfer
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-3
• NIOSHTIC Number:
  nn:00216273
• NTIS Accession Number:
  PB94117058
• Citation:
  NIOSH 1992 Aug:3 pages
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  False
• Source Full Name:
  NIOSH, 3 pages, 1 reference
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243280/cdc_243280_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]