Triphenyl phosphite: a type II organophosphorus compound-induced delayed neurotoxic agent.

Details

• Personal Author:
  Abou-Donia MB
• Description:
  The neurotoxicity of triphenyl-phosphite (101020) was studied. Following a brief discussion of phosphorus compounds and their chemical properties, including pentavalent and trivalent phosphorus containing compounds, specific attention was directed toward the action of organophosphorus esters. Acute toxicity is produced by these compounds through the inhibition of acetylcholinesterase (AChE), which is the enzyme responsible for hydrolyzing the neurotransmitter acetylcholine (ACh). Poisoning by organophosphorus compounds results in the accumulation of ACh in the central nervous system, creating tension, anxiety, restlessness, insomnia, headache, emotional instability, excessive dreaming, and nightmares. In addition to inhibiting AChE, some of these compounds produce a condition known as organophosphorus compound induced delayed neurotoxicity. Triaryl phosphites were reviewed with topics including acute convulsion action, in-vitro hydrolysis, differential neurotoxic actions of triphenyl phosphites resulting from differential routes of administration, neuropathological changes, the effect of age on sensitivity of chickens to triphenyl-phosphite induced delayed neurotoxicity, and the biochemical action. [Description provided by NIOSH]
• Subjects:
  Agriculture Insecticides Laboratories Nervous System Nervous System Diseases Occupational Health Organophosphates Safety
• Keywords:
  NIOSH-Grant; Neurotoxic-effects; Nervous-system-disorders; Neuropathy; Laboratory-animals; Agricultural-chemicals; Organo-phosphorus-compounds; Organo-phosphorus-pesticides
• ISBN:
  0121673456
• Publisher:
  Academic Press
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  327-351
• NIOSHTIC Number:
  nn:00213964
• Citation:
  Organophosphates: chemistry, fate, and effects. Chambers JE, Levi PE, eds. Cambridge, MA: Academic Press, 1992 Jan; :327-351
• Contact Point Address:
  Pharmacology Duke University Department of Pharmacology Durham, N C 27710
• CAS Registry Number:
  Triphenyl phosphite (CAS RN 101-02-0)
• Editor(s):
  Chambers JE; Levi PE
• Federal Fiscal Year:
  1992
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  Duke University, Durham, North Carolina
• Peer Reviewed:
  False
• Start Date:
  19790401
• Source Full Name:
  Organophosphates: chemistry, fate, and effects
• End Date:
  19980331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243261/cdc_243261_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]