Tissue distribution, elimination, and metabolism of O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens following daily dermal doses

Details

• Personal Author:
  Abdel-Kader HM ; Abou-Donia MB ; Abou-Donia SA
• Description:
  The absorption, tissue distribution, elimination, and metabolism of daily dermal small doses of carbon-14 labeled O-ethyl-O-4- nitrophenyl-phenylphosphonothioate (2104645) (EPN) were investigated in leghorn-hens. Three hens were treated with five daily dermal doses of EPN and then killed 1 day after the last dose in a preliminary experiment. In the main study, 12 hens were given ten daily dermal doses of 0.5mg/kg EPN. Hens were killed at 1, 5, 10, or 15 days after the tenth dose was administered. Hens treated with ten consecutive daily dermal doses of 0.5mg/kg EPN did not develop cholinergic or delayed neurotoxic effects. Administered in small daily doses, the EPN was efficiently absorbed, as indicated by the disappearance of radioactivity from the application site, disposition of carbon-14 in the tissues, and its excretion. No radioactivity was noted in the expired air. The findings indicated that the phenyl ring in the phenylphosphonothioate moiety of EPN was not completely degraded in the hen. The study confirmed the suggestion that pharmacokinetics and metabolism of organophosphorus compounds may contribute, at least in part, to species sensitivity to organophosphorus-induced delayed neurotoxicity. [Description provided by NIOSH]
• Subjects:
  Agriculture Energy Metabolism Insecticides Laboratories Nervous System Nervous System Diseases Occupational Health Organophosphates Safety
• Keywords:
  Agricultural-chemicals Body-burden Laboratory-animals Metabolic-study Nervous-system-disorders Neurotoxic-effects NIOSH-Grant NIOSH-Publication Organo-phosphorus-pesticides
• ISSN:
  0730-0913
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  391-404
• Volume:
  2
• Issue:
  6
• NIOSHTIC Number:
  nn:00214013
• Citation:
  J Amer Coll Toxicol 1983 Nov/Dec; 2(6):391-404
• Contact Point Address:
  Mohamed B. Abou-Donia, Department of Pharmacology, Duke University Medical Center, Durham, NC 27710
• CAS Registry Number:
  O-Ethyl O-(4-nitrophenyl) phenylphosphonothioate (CAS RN 2104-64-5)
• Federal Fiscal Year:
  1984
• Performing Organization:
  Duke University, Durham, North Carolina
• Peer Reviewed:
  True
• Start Date:
  19790401
• Source Full Name:
  Journal of the American College of Toxicology
• End Date:
  19980331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f9daffd1e0745c06d98dc8471ec6b7a347caf2a4a35816e79f58ea2ad352985bef71b759e7c9156c2b6079ba04f129ec1c98a6125e9fc66dd3c9bd51355791ae
• Download URL:
  https://stacks.cdc.gov/view/cdc/205800/cdc_205800_DS1.pdf
• File Type:
  [PDF - 802.73 KB ]