Monitoring styrene neurotoxicity with 3H-spiperone binding in lymphocytes.

Details

• Personal Author:
  Checkoway, Harvey ; Coccini T ; Costa LG ; Manzo L ; Rappaport S
• Description:
  The utility of monitoring tritium labeled spiperone (SP) binding in lymphocytes of workers exposed to styrene (100425) as a marker of neurotoxicity was determined. Thirty eight workers from a facility that manufactured luxury yachts and 17 nonexposed blood donor referents were studied. Seven exposure monitoring surveys were conducted at the site at roughly 6 week intervals. Personal samples were collected over the entire shift and analyzed by gas chromatography. Eight hour time weighted exposure at the site ranged from less than 1 to 91 parts per million (ppm). The median tritium labeled SP binding was greater among the workers than the volunteers, 67 versus 57 femtomoles/10(6) lymphocytes. Comparisons between workers grouped according to exposure level were given separately for males and females, and workers' styrene levels were averaged. No discernible trend was noted among the men. Female workers, however, demonstrated an increased tritium labeled SP binding with increased exposure levels. The authors stress that it would be beneficial to develop a noninvasive technique for monitoring exposures to neurotoxic chemicals, and that tritium labeled SP binding in lymphocytes appears to offer promise along these lines. [Description provided by NIOSH]
• Subjects:
  Blood Hematologic Tests Nervous System Nervous System Diseases Occupational Exposure Occupational Health Safety Sex Characteristics Ships
• Keywords:
  NIOSH-Grant; Neurotoxic-effects; Blood-cells; Biological-monitoring; Blood-analysis; Nervous-system-disorders; Sex-factors; Humans; Occupational-exposure; Boat-manufacturing-industry
• ISBN:
  9780444813374
• Publisher:
  Excerpta Medica
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  197-200
• NIOSHTIC Number:
  nn:00213957
• Citation:
  Occupational Epidemiology: Proceedings of the Seventh International Symposium on Epidemiology in Occupational Health, Tokyo, Japan, October 11-13, 1989. Sakurai H, Okazaki I, Omae-K, eds., New York: Excerpta Medica, 1990 Jun; :197-200
• Contact Point Address:
  Environmental Health University of Washington Dept/environmental Hlth/sc-34 Seattle, WA 98195
• CAS Registry Number:
  Styrene (CAS RN 100-42-5)
• Editor(s):
  Sakurai H; Okazaki I; Omae K
• Federal Fiscal Year:
  1990
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  University of Washington, Seattle, Washington
• Peer Reviewed:
  False
• Start Date:
  19881201
• Source Full Name:
  Occupational Epidemiology: Proceedings of the Seventh International Symposium on Epidemiology in Occupational Health, Tokyo, Japan, October 11-13, 1989
• End Date:
  19921130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243254/cdc_243254_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]