Comparison of Patella Lead with Blood Lead and Tibia Lead and Their Associations with Neurobehavioral Test Scores

Details

• Personal Author:
  Bolla KI ; Dorsey CD ; Lee BK ; Lee GS ; Lee SS ; Schwartz BS ; Shi W ; Todd AC ; Weaver VM ; Bolla KI ; Dorsey CD ; Lee BK ; Lee GS ; Lee SS ; Schwartz BS ; Shi W ; Todd AC ; Weaver VM
• Description:
  OBJECTIVE: Lead exposure in adults is associated with worse cognitive function in cross-sectional and longitudinal studies. Previous studies have mainly examined relations with blood lead or cortical bone lead; few have examined trabecular bone lead. METHODS: We performed a cross-sectional analysis of the relations of patella lead and other lead biomarkers with measures of neurobehavioral and peripheral nervous system function in 652 lead workers. RESULTS: Patella lead was found to be associated with worse performance on seven of 19 tests of manual dexterity, sensory vibration threshold, and depressive symptoms. The associations of patella lead with cognitive function were essentially similar to those with blood lead or tibia lead but of somewhat lower magnitude. CONCLUSIONS: In this study, measurement of patella lead did not aid causal inference regarding cognitive effects when compared with blood lead and tibia lead. [Description provided by NIOSH]
• Subjects:
  Aging Biomarkers Blood Environmental Monitoring Hematologic Tests Lead Men Nervous System Nervous System Diseases Occupational Health Poisoning Safety

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• Keywords:
  Age-groups Blood-poisoning Blood-samples Exposure-assessment Exposure-levels Humans Lead-compounds Nervous-system Nervous-system-disorders Poisons
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Maryland ; New York ; OSHA Region 2 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  489-496
• Volume:
  48
• Issue:
  5
• NIOSHTIC Number:
  nn:20037533
• Citation:
  J Occup Environ Med 2006 May; 48(5):489-496
• Contact Point Address:
  Byung-Kook Lee, MD, Soonchunhyang University, College of Medicine, 646 Eupnae-ri, Shinchang-myun, Asan-Si, Choongnam, 336-745, Korea
• Email:
  bklee@sch.ac.kr
• CAS Registry Number:
  Lead (CAS RN 7439-92-1) ; Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2006
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9fb04d2a56db46a8aa1dd728d884c459972b24e2ea7fa6c4c5f072282c23196bf9682ebd5abc355710f386d530b1553e16153c134e842f10aa007746a71d1e8b
• Download URL:
  https://stacks.cdc.gov/view/cdc/188612/cdc_188612_DS1.pdf
• File Type:
  [PDF - 92.66 KB ]