Molecular Discrimination of Sheep Bovine Spongiform Encephalopathy from Scrapie

Pirisinu, Laura; Migliore, Sergio; Di Bari, Michele Angelo; Esposito, Elena; Baron, Thierry; D’Agostino, Claudia; De Grossi, Luigi; Vaccari, Gabriele; Agrimi, Umberto; Nonno, Romolo

doi:10.3201/eid1704.101215

i

Molecular Discrimination of Sheep Bovine Spongiform Encephalopathy from Scrapie

Supporting Files Public Domain

Apr 2011
By Pirisinu, Laura ; Migliore, Sergio ; Di Bari, Michele Angelo ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Pirisinu, Laura ; Migliore, Sergio ; Di Bari, Michele Angelo ; Esposito, Elena ; Baron, Thierry ; D’Agostino, Claudia ; De Grossi, Luigi ; Vaccari, Gabriele ; Agrimi, Umberto ; Nonno, Romolo
Description:

Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc cleavage, allowed differentiation of classical scrapie, including CH1641-like, from natural goat BSE and experimental sheep BSE.
Subjects:

Animals Bovine Spongiform Encephalopathy BSE Cattle CH1641 Dispatch Encephalopathy, Bovine Spongiform Prions Protein Denaturation Protein Stability PrPSc Proteins Scrapie Sheep Solubility Transmissible Spongiform Encephalopathy Western Blot
Source:

Emerg Infect Dis. 17(4):695-698.
Document Type:

Journal Article
Volume:

17
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:8174d042987579b10adf40426cd516a4ef8fed0f73a3e8d404db6b8bd3905ca9
Download URL:

https://stacks.cdc.gov/view/cdc/24315/cdc_24315_DS1.pdf
File Type:

[PDF - 359.15 KB ]

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.