Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1704.101215
Personal Author:
Pirisinu, Laura ; Migliore, Sergio ; Di Bari, Michele Angelo ; Esposito, Elena ; Baron, Thierry ; ... More +
Pirisinu, Laura ; Migliore, Sergio ; Di Bari, Michele Angelo ; Esposito, Elena ; Baron, Thierry ; D’Agostino, Claudia ; De Grossi, Luigi ; Vaccari, Gabriele ; Agrimi, Umberto ; Nonno, Romolo Less -
Description:
Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc cleavage, allowed differentiation of classical scrapie, including CH1641-like, from natural goat BSE and experimental sheep BSE.
Subject:
[+]
Animals
Bovine Spongiform Encephalopathy
BSE
Cattle
CH1641
Dispatch
Encephalopathy, Bovine Spongiform
Prions
Protein Denaturation
Protein Stability
PrPSc Proteins
Scrapie
Sheep
Solubility
Transmissible Spongiform Encephalopathy
Western Blot
Scrapie
Sheep

Source:
Emerg Infect Dis. 17(4):695-698.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:8174d042987579b10adf40426cd516a4ef8fed0f73a3e8d404db6b8bd3905ca9
File Type:

Supporting Files

• 	license.txt	txt
  	10-1215-F1.gif	gif
  	10-1215-F1.jpg	jpeg
  	10-1215-F2.gif	gif
  	10-1215-F2.jpg	jpeg
  	10-1215-Techapp.pdf	pdf
  	10-1215_finalD.nxml	txt

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