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Molecular Discrimination of Sheep Bovine Spongiform Encephalopathy from Scrapie
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  1. Molecular Typing of Protease-Resistant Prion Protein in Transmissible Spongiform Encephalopathies of Small Ruminants, France, 2002–2009
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    Vulin, Johann; Biacabe, Anne-Gaëlle; Cazeau, Géraldine; Calavas, Didier; Baron, Thierry;
    Published:
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    Description:
    The agent that causes bovine spongiform encephalopathy (BSE) may be infecting small ruminants, which could have serious implications for human health. To distinguish BSE from scrapie and to examine the molecular characteristics of the protease-resist...
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  2. Classic Scrapie in Sheep with the ARR/ARR Prion Genotype in Germany and France
    Personal Author:
    Groschup, Martin H.; Lacroux, Caroline; Buschmann, Anne; Lühken, Gesine; Mathey, Jacinthe; Eiden, Martin; Lugan, Séverine; Hoffmann, Christine; Espinosa, Juan Carlos; Baron, Thierry; Torres, Juan Maria; Erhardt, Georg; Andreoletti, Olivier;
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    Aug 2007
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    Emerg Infect Dis. 13(8):1201-1207.
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    In the past, natural scrapie and bovine spongiform encephalopathy (BSE) infections have essentially not been diagnosed in sheep homozygous for the A136R154R171 haplotype of the prion protein. This genotype was therefore assumed to confer resistance t...
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  3. Rapid Typing of Transmissible Spongiform Encephalopathy Strains with Differential ELISA
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    Simon, Stéphanie; Nugier, Jérôme; Morel, Nathalie; Boutal, Hervé; Créminon, Christophe; Benestad, Sylvie L.; Andréoletti, Olivier; Lantier, Frédéric; Bilheude, Jean-Marc; Feyssaguet, Muriel; Biacabe, Anne-Gaëlle; Baron, Thierry; Grassi, Jacques;
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    Emerg Infect Dis. 14(4):608-616.
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    The bovine spongiform encephalopathy (BSE) agent has been transmitted to humans, leading to variant Creutzfeldt-Jakob disease. Sheep and goats can be experimentally infected by BSE and have been potentially exposed to natural BSE; however, whether BS...
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  4. Phenotypic Similarity of Transmissible Mink Encephalopathy in Cattle and L-type Bovine Spongiform Encephalopathy in a Mouse Model
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    Baron, Thierry; Bencsik, Anna; Biacabe, Anne-Gaëlle; Morignat, Eric; Bessen, Richard A.;
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    Dec 2007
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    Emerg Infect Dis. 13(12):1887-1894.
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    Transmissible mink encepholapathy (TME) is a foodborne transmissible spongiform encephalopathy (TSE) of ranch-raised mink; infection with a ruminant TSE has been proposed as the cause, but the precise origin of TME is unknown. To compare the phenotyp...
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  5. Transgenic Mice Expressing Porcine Prion Protein Resistant to Classical Scrapie but Susceptible to Sheep Bovine Spongiform Encephalopathy and Atypical Scrapie
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    Espinosa, Juan-Carlos; Herva, María-Eugenia; Andréoletti, Olivier; Padilla, Danielle; Lacroux, Caroline; Cassard, Hervé; Lantier, Isabelle; Castilla, Joaquin; Torres, Juan-María;
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    Emerg Infect Dis. 15(8):1214-1221.
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    How susceptible pigs are to infection with sheep prions is unknown. We show, through transmission experiments in transgenic mice expressing porcine prion protein (PrP), that the susceptibility of this mouse model to bovine spongiform encephalopathy (...
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