Molecular Discrimination of Sheep Bovine Spongiform Encephalopathy from Scrapie

Pirisinu, Laura; Migliore, Sergio; Di Bari, Michele Angelo; Esposito, Elena; Baron, Thierry; D’Agostino, Claudia; De Grossi, Luigi; Vaccari, Gabriele; Agrimi, Umberto; Nonno, Romolo

doi:10.3201/eid1704.101215

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Molecular Discrimination of Sheep Bovine Spongiform Encephalopathy from Scrapie

Apr 2011
By Pirisinu, Laura ; Migliore, Sergio ; Di Bari, Michele Angelo ; ...
http://dx.doi.org/10.3201/eid1704.101215
Source: Emerg Infect Dis. 17(4):695-698.

[PDF-359.15 KB]

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Alternative Title:

Emerg Infect Dis
Personal Author:

Pirisinu, Laura ; Migliore, Sergio ; Di Bari, Michele Angelo ; Esposito, Elena ; Baron, Thierry ; ... More +

Pirisinu, Laura ; Migliore, Sergio ; Di Bari, Michele Angelo ; Esposito, Elena ; Baron, Thierry ; D’Agostino, Claudia ; De Grossi, Luigi ; Vaccari, Gabriele ; Agrimi, Umberto ; Nonno, Romolo Less -
Description:

Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc cleavage, allowed differentiation of classical scrapie, including CH1641-like, from natural goat BSE and experimental sheep BSE.
Subjects:

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Animals Bovine Spongiform Encephalopathy BSE Cattle CH1641 Dispatch Encephalopathy, Bovine Spongiform Prions Protein Denaturation Protein Stability PrPSc Proteins Scrapie Sheep Solubility Transmissible Spongiform Encephalopathy Western Blot
Source:

Emerg Infect Dis. 17(4):695-698.
Document Type:

Journal Article
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

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urn:sha256:8174d042987579b10adf40426cd516a4ef8fed0f73a3e8d404db6b8bd3905ca9
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https://stacks.cdc.gov/view/cdc/24315/cdc_24315_DS1.pdf
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