Molecular Discrimination of Sheep Bovine Spongiform Encephalopathy from Scrapie

Pirisinu, Laura; Migliore, Sergio; Di Bari, Michele Angelo; Esposito, Elena; Baron, Thierry; D’Agostino, Claudia; De Grossi, Luigi; Vaccari, Gabriele; Agrimi, Umberto; Nonno, Romolo

doi:10.3201/eid1704.101215

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Molecular Discrimination of Sheep Bovine Spongiform Encephalopathy from Scrapie

Published Date:

Apr 2011

Publisher's site:

http://dx.doi.org/10.3201/eid1704.101215 New Site Icon

Source:

Emerg Infect Dis. 17(4):695-698.

[PDF - 359.15 KB]

Details:

Personal Authors:

Pirisinu, Laura ; Migliore, Sergio ; Di Bari, Michele Angelo ; Esposito, Elena ; Baron, Thierry ; ... More ▼

Keywords:

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Description:

Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc cleavage, allowed differentiation of classical scrapie, including CH1641-like, from natural goat BSE and experimental sheep BSE.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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