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Hepatitis A Virus Vaccine Escape Variants and Potential New Serotype Emergence
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  1. Hepatitis A Virus Vaccine Escape Variants and Potential New Serotype Emergence
    Personal Author:
    Pérez-Sautu, Unai; Costafreda, M. Isabel; Caylà, Joan; Tortajada, Cecilia; Lite, Josep; Bosch, Albert; Pintó, Rosa M.;
    Published:
    Apr 2011
    Source:
    Emerg Infect Dis. 17(4):734-737.
    Description:
    Six hepatitis A virus antigenic variants that likely escaped the protective effect of available vaccines were isolated, mostly from men who have sex with men. The need to complete the proper vaccination schedules is critical, particularly in the immu...
    File Type:
    Filetype[PDF - 167.21 KB]
  2. Disparate distribution of hepatitis B virus genotypes in four sub-Saharan African countries
    Personal Author:
    Forbi, Joseph C.; Ben-Ayed, Yousr; Xia, Guo-liang; Vaughan, Gilberto; Drobeniuc, Jan; Switzer, William M.; Khudyakov, Yury E.;
    Published:
    Jul 17 2013
    Source:
    J Clin Virol. 58(1):59-66.
    Description:
    Background : Hepatitis B virus (HBV) places a substantial health burden on Africa. Here, we investigated genetic diversity of HBV variants circulating in 4 countries of sub-Saharan Africa using archived samples. In total, 1492 plasma samples were tes...
    File Type:
    Filetype[PDF - 677.24 KB]
  3. Detecting Hepatitis B Surface Antigen Mutants
    Personal Author:
    Coleman, Paul F.
    Published:
    Feb 2006
    Source:
    Emerg Infect Dis. 12(2):198-203.
    Description:
    Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to ...
    File Type:
    Filetype[PDF - 122.63 KB]
  4. Quasispecies structure and persistence of RNA viruses.
    Personal Author:
    Domingo, E.; Baranowski, E.; Ruiz-Jarabo, C. M.; Martín-Hernández, A. M.; Sáiz, J. C.; Escarmís, C.;
    Published:
    1998 Oct-Dec
    Source:
    Emerg Infect Dis. 4(4):521-527.
    Description:
    Viral quasispecies are closely related (but nonidentical) mutant and recombinant viral genomes subjected to continuous genetic variation, competition, and selection. Quasispecies structure and dynamics of replicating RNA enable virus populations to p...
    File Type:
    Filetype[PDF - 77.67 KB]
  5. Emergence of Double- and Triple-Gene Reassortant G1P[8] Rotaviruses Possessing a DS-1-Like Backbone after Rotavirus Vaccine Introduction in Malawi
    Personal Author:
    Jere, Khuzwayo C.; Chaguza, Chrispin; Bar-Zeev, Naor; Lowe, Jenna; Peno, Chikondi; Kumwenda, Benjamin; Nakagomi, Osamu; Tate, Jacqueline E.; Parashar, Umesh D.; Heyderman, Robert S.; French, Neil; Cunliffe, Nigel A.; Iturriza-Gomara, Miren;
    Published:
    Jan 17 2018
    Source:
    J Virol. 2018; 92(3).
    Description:
    To combat the high burden of rotavirus gastroenteritis, multiple African countries have introduced rotavirus vaccines into their childhood immunization programs. Malawi incorporated a G1P[8] rotavirus vaccine (Rotarix) into its immunization schedule ...
    File Type:
    Filetype[PDF - 5.51 MB]