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Hepatitis A Virus Vaccine Escape Variants and Potential New Serotype Emergence
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  1. Hepatitis A Virus Vaccine Escape Variants and Potential New Serotype Emergence
    Personal Author:
    Pérez-Sautu, Unai; Costafreda, M. Isabel; Caylà, Joan; Tortajada, Cecilia; Lite, Josep; Bosch, Albert; Pintó, Rosa M.;
    Published Date:
    Apr 2011
    Source:
    Emerg Infect Dis. 17(4):734-737.
    Description:
    Six hepatitis A virus antigenic variants that likely escaped the protective effect of available vaccines were isolated, mostly from men who have sex with men. The need to complete the proper vaccination schedules is critical, particularly in the immu...
    File Type:
    Filetype[PDF - 167.21 KB]
  2. Disparate distribution of hepatitis B virus genotypes in four sub-Saharan African countries
    Personal Author:
    Forbi, Joseph C.; Ben-Ayed, Yousr; Xia, Guo-liang; Vaughan, Gilberto; Drobeniuc, Jan; Switzer, William M.; Khudyakov, Yury E.;
    Published Date:
    Jul 17 2013
    Source:
    J Clin Virol. 58(1):59-66.
    Description:
    BackgroundHepatitis B virus (HBV) places a substantial health burden on Africa. Here, we investigated genetic diversity of HBV variants circulating in 4 countries of sub-Saharan Africa using archived samples. In total, 1492 plasma samples were tested...
    File Type:
    Filetype[PDF - 677.24 KB]
  3. Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy
    Personal Author:
    Fusco, Dahlene N.; Ganova-Raeva, Lilia; Khudyakov, Yury; Punkova, Lili; Mohamed, Aisha; Cheon, Scarlett Se Yun; Koirala, Prapti; Andersson, Karin L.; Jourdain, Gonzague; Sureau, Camille; Chung, Raymond T.; Lauer, Georg;
    Published Date:
    Apr 30 2018
    Source:
    Front Med (Lausanne). 2018; 5.
    Description:
    A 76-year-old Cambodian man co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) 6c-1 presented for care. HBV DNA was intermittently detectable despite anti-HBs levels being above the protective threshold. During treatment for HCV, HB...
    File Type:
    Filetype[PDF - 229.43 KB]
  4. Quasispecies structure and persistence of RNA viruses.
    Personal Author:
    Domingo, E.; Baranowski, E.; Ruiz-Jarabo, C. M.; Martín-Hernández, A. M.; Sáiz, J. C.; Escarmís, C.;
    Published Date:
    1998 Oct-Dec
    Source:
    Emerg Infect Dis. 4(4):521-527.
    Description:
    Viral quasispecies are closely related (but nonidentical) mutant and recombinant viral genomes subjected to continuous genetic variation, competition, and selection. Quasispecies structure and dynamics of replicating RNA enable virus populations to p...
    File Type:
    Filetype[PDF - 77.67 KB]
  5. Detecting Hepatitis B Surface Antigen Mutants
    Personal Author:
    Coleman, Paul F.
    Published Date:
    Feb 2006
    Source:
    Emerg Infect Dis. 12(2):198-203.
    Description:
    Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to ...
    File Type:
    Filetype[PDF - 122.63 KB]