Hepatitis A Virus Vaccine Escape Variants and Potential New Serotype Emergence
Published Date:Apr 2011
Source:Emerg Infect Dis. 17(4):734-737.
Keywords:Amino Acid Substitution
Capsid Structural Constraints
Hepatitis A Vaccines
Hepatitis A Virus
Vaccine Escape Mutants
Vaccine Escape Variants
Viral Structural Proteins
Description:Six hepatitis A virus antigenic variants that likely escaped the protective effect of available vaccines were isolated, mostly from men who have sex with men. The need to complete the proper vaccination schedules is critical, particularly in the immunocompromised population, to prevent the emergence of vaccine-escaping variants.
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