Hepatitis A Virus Vaccine Escape Variants and Potential New Serotype Emergence

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Pérez-Sautu, Unai ; Costafreda, M. Isabel ; Caylà, Joan ; Tortajada, Cecilia ; Lite, Josep ; Bosch, Albert ; Pintó, Rosa M.
• Description:
  Six hepatitis A virus antigenic variants that likely escaped the protective effect of available vaccines were isolated, mostly from men who have sex with men. The need to complete the proper vaccination schedules is critical, particularly in the immunocompromised population, to prevent the emergence of vaccine-escaping variants.
• Subjects:
  Amino Acid Substitution Antigenic Variation Capsid Structural Constraints Codon Usage Dispatch Hepatitis A Hepatitis A Vaccines Hepatitis A Virus Humans Immunocompromised Host Male Molecular Epidemiology Mutation Phylogeny Quasispecies Rare Codon Vaccination Vaccine Escape Mutants Vaccine Escape Variants Viral Structural Proteins Viruses

  More +
• Source:
  Emerg Infect Dis. 17(4):734-737.
• Pubmed ID:
  21470474
• Pubmed Central ID:
  PMC3377408
• Document Type:
  Journal Article
• Volume:
  17
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:dbddcd9812274cb2bf035fe10355ea585e8b05444fc14687adbb19151e6a336bb12040c269b6a6db2d800faede7ad45f94f67e6523810457734f3518fc40dfda
• Download URL:
  https://stacks.cdc.gov/view/cdc/24313/cdc_24313_DS1.pdf
• File Type:
  [PDF - 167.21 KB ]