Potential role of platelet-activating factor in development of occupational lung disease: action as an activator or potentiator of pulmonary phagocytes.

Details

• Personal Author:
  Castranova, Vincent ; Dyke K ; Kang JH ; Pailes WH
• Description:
  This study was designed to investigate whether platelet activating factor may be important in the inflammatory response of the lung to occupational dusts. The in-vitro exposure of alveolar macrophages to cotton dust at 4mg/kg, silica (14808607) at 10mg/ml, or coal dust at 10mg/kg caused a release of picomole levels of platelet activating factor with cotton dust being the most potent and coal dust the least. The platelet activating factor was released from alveolar macrophage about 10 minutes after in-vitro silica exposure. Platelet activating factor is a direct stimulant of polymorphonuclear leukocytes increasing chemiluminescence 2.3 times above control. The response of polymorphonuclear leukocytes to a second stimulant was also potentiated by platelet activating factor. Platelet activating factor was not a direct stimulant of alveolar macrophages in-vitro, having no stimulatory effect on chemiluminescence or superoxide anion release. Platelet activating factor did potentiate zymosan stimulated activation of chemiluminescence and superoxide release from alveolar macrophages by 117 and 30, respectively. The authors conclude that exposure of lung tissue to occupational dusts results in the release of platelet activating factor which may activate polymorphonuclear leukocytes and potentiate the responsiveness of alveolar macrophages to dust. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no PDF
• Subjects:
  Blood Dust Hematologic Tests Immune System Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide
• Keywords:
  NIOSH-Author; Respiratory-system-disorders; Lung-cells; Alveolar-cells; Immunology; Blood-analysis; Blood-cells; Dust-exposure; Dust-inhalation; Silica-dusts; Plant-dusts
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-30
• NIOSHTIC Number:
  nn:00205496
• NTIS Accession Number:
  PB92176775
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, 1992 Jan; :1-30
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  False
• Source Full Name:
  Potential role of platelet-activating factor in development of occupational lung disease: action as an activator or potentiator of pulmonary phagocytes.
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243125/cdc_243125_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]