The cellular target site in distal axonopathies.

Details

• Personal Author:
  Pellegrino RG ; Politis MJ ; Schaumburg HH ; Spencer PS
• Description:
  Direct evidence was presented to support the idea that the causation of axonal degeneration in central/peripheral distal axonopathies should be sought in the nerve fiber rather than in the neuronal perikaryon. Evidence suggested that abnormalities of slow and fast axonal transport are responsible for the fine structural changes that precede nerve fiber breakdown. The usefulness of experimental toxicants for exploring the etiology and pathogenesis of human axonal neuropathies was discussed. Several factors must be included in choosing an appropriate toxicant to test hypotheses of direct toxic damage to the nerve fiber. The compound must be a primary neurotoxic agent, not one that requires metabolic activation to exert its effect. It must cause a pathologic change of a characteristic and readily recognizable type, and a chemically related nonneurotoxic compound must be available for negative control. According to the authors, axonal neurotoxins such as 2,5- hexanedione (110134) (2,5-HD) may continue to be important in the elucidation of these diseases, as well as in the expansion of the understanding of the biochemical mechanisms underlying axonal transport. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Nervous System Nervous System Diseases Occupational Health Safety
• Keywords:
  NIOSH-Grant; Neurotoxic-effects; Nervous-system-disorders; Cell-damage; Cell-function; Neuropathology; Toxic-effects
• ISBN:
  9780471095071
• Publisher:
  John Wiley and Sons
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  87-101
• NIOSHTIC Number:
  nn:00185748
• Citation:
  Disorders of the motor unit. Schotland DL, ed., New York: John Wiley and Sons, 1982 Jan; :87-101
• Contact Point Address:
  Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
• CAS Registry Number:
  2,5-Hexanedione (CAS RN 110-13-4)
• Editor(s):
  Schotland DL
• Federal Fiscal Year:
  1982
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  False
• Start Date:
  19751101
• Source Full Name:
  Disorders of the motor unit
• End Date:
  19850331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/242740/cdc_242740_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]