Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1612.100772
Personal Author:
Liu, Catherine ; Schwartz, Brian S. ; Vallabhaneni, Snigdha ; Nixon, Michael ; Chin-Hong, Peter V. ; ... More +
Liu, Catherine ; Schwartz, Brian S. ; Vallabhaneni, Snigdha ; Nixon, Michael ; Chin-Hong, Peter V. ; Miller, Steven A. ; Chiu, Charles ; Damon, Lloyd ; Drew, W. Lawrence Less -
Description:
To assess outcomes of patients with hematologic malignancy and pandemic (H1N1) 2009 infection, we reviewed cases during June-December 2009 at the University of California San Francisco Medical Center. Seventeen (63%) and 10 (37%) patients had upper respiratory tract infection (URTI) and lower respiratory tract infection (LRTI), respectively. Cough (85%) and fever (70%) were the most common signs; 19% of patients had nausea, vomiting, or diarrhea. Sixty-five percent of URTI patients were outpatients; 35% recovered without antiviral therapy. All LRTI patients were hospitalized; half required intensive care unit admission. Complications included acute respiratory distress syndrome, pneumomediastinum, myocarditis, and development of oseltamivir-resistant virus; 3 patients died. Of the 3 patients with nosocomial pandemic (H1N1) 2009, 2 died. Pandemic (H1N1) 2009 may cause serious illness in patients with hematologic malignancy, primarily those with LRTI. Rigorous infection control, improved techniques for diagnosing respiratory disease, and early antiviral therapy can prevent nosocomial transmission and optimize patient care.
Subject:
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Academic Medical Centers
Adolescent
Adult
Aged
Aged, 80 And Over
Antiviral Agents
Child
Cross Infection
Drug Therapy, Combination
Female
Hematologic Neoplasms
Humans
Influenza, Human
Influenza A Virus, H1N1 Subtype
Male
Middle Aged
Pandemics
Respiratory Tract Infections
Seasons

Source:
Emerg Infect Dis. 16(12):1910-1917.
Document Type:
Journal Article
Place as Subject:
San Francisco, CA
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:b7e71c77b03310b23ff12957152500b4e795c00de1228b9363a55ae097307574
File Type:

Supporting Files

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  	10-0772_finalRCME_PMC.nxml	txt
  	license.txt	txt

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