Pandemic (H1N1) 2009 Infection in Patients with Hematologic Malignancy

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Liu, Catherine ; Schwartz, Brian S. ; Vallabhaneni, Snigdha ; Nixon, Michael ; Chin-Hong, Peter V. ; Miller, Steven A. ; Chiu, Charles ; Damon, Lloyd ; Drew, W. Lawrence
• Description:
  To assess outcomes of patients with hematologic malignancy and pandemic (H1N1) 2009 infection, we reviewed cases during June-December 2009 at the University of California San Francisco Medical Center. Seventeen (63%) and 10 (37%) patients had upper respiratory tract infection (URTI) and lower respiratory tract infection (LRTI), respectively. Cough (85%) and fever (70%) were the most common signs; 19% of patients had nausea, vomiting, or diarrhea. Sixty-five percent of URTI patients were outpatients; 35% recovered without antiviral therapy. All LRTI patients were hospitalized; half required intensive care unit admission. Complications included acute respiratory distress syndrome, pneumomediastinum, myocarditis, and development of oseltamivir-resistant virus; 3 patients died. Of the 3 patients with nosocomial pandemic (H1N1) 2009, 2 died. Pandemic (H1N1) 2009 may cause serious illness in patients with hematologic malignancy, primarily those with LRTI. Rigorous infection control, improved techniques for diagnosing respiratory disease, and early antiviral therapy can prevent nosocomial transmission and optimize patient care.
• Subjects:
  Academic Medical Centers Adolescent Adult Aged Aged, 80 And Over Antiviral Agents Child Cross Infection Drug Therapy, Combination Female Hematologic Neoplasms Humans Influenza, Human Influenza A Virus, H1N1 Subtype Male Middle Aged Pandemics Respiratory Tract Infections Seasons

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• Source:
  Emerg Infect Dis. 16(12):1910-1917.
• Document Type:
  Journal Article
• Place as Subject:
  San Francisco, CA
• Volume:
  16
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b7e71c77b03310b23ff12957152500b4e795c00de1228b9363a55ae097307574
• Download URL:
  https://stacks.cdc.gov/view/cdc/24274/cdc_24274_DS1.pdf
• File Type:
  [PDF - 235.52 KB ]