Photosensitivity caused by pesticides.

Details

• Personal Author:
  Ando Y ; Horiuchi N
• Description:
  A study of the incidence of pesticide induced photosensitivity in a farming population was conducted. The cohort consisted of 88 patients with pesticide dermatitis treated at Saku Central Hospital, Japan, over a 3 year period. Fifteen patients (11 males) had solar dermatitis. Fifty two subjects were evaluated in photopatch tests with gramoxone (1910425), trifluralin (1582098), TOK (1836755) (NIP), daconil (1897456), Des (62737) (DDVP), sumithion (122145), tedion (116290), mitran (80331), CNP, or kelthane (115322). The ultraviolet absorption spectra of the compounds were measured. The minimal erythema doses (MEDs) were determined in 56 patients. The data were compared with previously published data on the erythemic response of patients with solar dermatitis. The amount of ultraviolet radiation reaching the surface on sunny days was measured monthly for 1 year. Approximately 55.4 percent of the patients had MEDs of less than 3 minutes. Comparison with previously published data showed that 66.1 percent of other solar dermatitis patients and 88.7 percent of the comparison subjects had MEDs of less than 3 minutes. The photopositivity rates were: gramoxone 21.2 percent, trifluralin 7.7 percent, NIP 5.8 percent, daconil 19.2 percent, DDVP 15.4 percent, sumithion 5.8 percent, and tedion and mitran 3.8 percent. CNP and kelthane gave negative responses. The intensity of incident ultraviolet radiation was greatest in March and April. The absorption spectra suggested that NIP may be phototoxic and DDVP and tedion could be photoallergenic. Sumithion and trifluralin could induce phototoxicity and photoallergy. The authors conclude that 17 percent of the patients with pesticide dermatitis show phototoxic lesions. The maximum solar ultraviolet radiation reaches the ground in the spring. The MEDs of patients with pesticide dermatitis are greater than in healthy individuals. Gramoxone, daconil, DDVP, trifluralin, NIP, and sumithion are photosensitizing agents. [Description provided by NIOSH]
• Subjects:
  Agriculture Epidemiology Occupational Exposure Occupational Health Radiation Safety Skin Skin Diseases Ultraviolet Rays
• Keywords:
  NIOSH-Grant; Grants-other; Skin-disorders; Epidemiology; Agricultural-workers; Skin-exposure; Agricultural-chemicals; Ultraviolet-radiation; Occupational-exposure; Dose-response; Patch-tests
• Publisher:
  International Association of Agricultural Medicine
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  Iowa ; OSHA Region 7 ; OSHA Region 8 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  279-284
• NIOSHTIC Number:
  nn:00185397
• Citation:
  Proceedings of the VII International Congress of Rural Medicine, September 17-21, Salt Lake City, Utah. International Association of Agricultural Medicine, 1978 Sep; :279-284
• Contact Point Address:
  Prev Med & Environmental Hlth University of Iowa Inst/agric Med & Environ Hlth Iowa Oakdale, Iowa 52319
• CAS Registry Number:
  Chlorfenson (CAS RN 80-33-1) ; Chlorothalonil (CAS RN 1897-45-6) ; Dichlorvos (CAS RN 62-73-7) ; Dicofol (CAS RN 115-32-2) ; Fenitrothion (CAS RN 122-14-5) ; Methyl viologen (CAS RN 1910-42-5) ; Nitrofen (CAS RN 1836-75-5) ; Tetradifon (CAS RN 116-29-0) ; Trifluralin (CAS RN 1582-09-8)
• Federal Fiscal Year:
  1978
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  University of Iowa, Iowa City, Iowa
• Peer Reviewed:
  False
• Start Date:
  19770201
• Source Full Name:
  Proceedings of the VII International Congress of Rural Medicine, September 17-21, Salt Lake City, Utah
• End Date:
  19800229
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/242724/cdc_242724_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]