Biochemical, Pharmacological and Tumorigenic Studies on a Composite of Drinking Water Carcinogens and Mutagens Utilizing Aquatic Animals.

Details

• Personal Author:
  Hawkins WE ; Overstreet RM ; Walker WW
• Description:
  This study was performed to determine the different reactions of various fish to carcinogenic compounds, to demonstrate the wide variety of neoplasms which can develop in fish, to demonstrate that a combination of halomethanes can induce neoplasia in fish, and to show the effect of the genotoxic compound methylazoxymethanol- acetate (592621) (MAM-Ac) in a model. Fish used in the study included the Japanese-medaka, king-cobra-guppy, sheepshead-minnow, Gulf-killifish, inland-silverside, rivulus, and fathead-minnow. The chemicals used in the study included a mixture of six trihalomethanes (THM), specifically chloroform (67663), bromodichloromethane (75274), chlorodibromomethane (124481), bromoform (75252), trichloroethylene (79016), and carbon- tetrachloride (56235). Also included were the following single compounds: vinylidene-chloride (75354), trichloroethylene, and bis(2-chloroethyl)ether (111444). The authors conclude that some small aquarium fish are good carcinogenicity models as they are sensitive to induction of a wide variety of neoplasms which have a short latency period. The fish also have a low number of spontaneous neoplasms, are cheap to maintain, and most susceptible tissues can be screened for neoplasms in one or a few microscopic slides. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Environmental Pollution Halothane Hydrocarbons Methane Mutagens Occupational Health Safety
• Keywords:
  Carcinogens; Chlorinated-hydrocarbons; Mutagens; Halogenated-hydrocarbons; Environmental-contamination; Animal-studies; Halogenated-compounds; Methanes
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  23-39
• NIOSHTIC Number:
  nn:00180850
• Citation:
  NIOSH 1988:23-39
• CAS Registry Number:
  Bis(2-chloroethyl) ether (CAS RN 111-44-4) ; Bromodichloromethane (CAS RN 75-27-4) ; Bromoform (CAS RN 75-25-2) ; Carbon tetrachloride (CAS RN 56-23-5) ; Chloroform (CAS RN 67-66-3) ; Dibromochloromethane (CAS RN 124-48-1) ; Methanol, 1-(2-methyl-2-oxidodiazenyl)-, 1-acetate (CAS RN 592-62-1) ; Trichloroethylene (CAS RN 79-01-6) ; Vinylidene chloride (CAS RN 75-35-4)
• Federal Fiscal Year:
  1988
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of the Fourth NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, April 22-23, 1986, Rockville, Maryland, NIH Publication No. 88-2960
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/242562/cdc_242562_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]