Alkhurma Hemorrhagic Fever in Humans, Najran, Saudi Arabia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Alzahrani, Abdullah G. ; Al Shaiban, Hassan M. ; Al Mazroa, Mohammad A. ; Al-Hayani, Osama ; MacNeil, Adam ; Rollin, Pierre E. ; Memish, Ziad A.
• Description:
  Alkhurma virus is a flavivirus, discovered in 1994 in a person who died of hemorrhagic fever after slaughtering a sheep from the city of Alkhurma, Saudi Arabia. Since then, several cases of Alkhurma hemorrhagic fever (ALKHF), with fatality rates up to 25%, have been documented. From January 1, 2006, through April 1, 2009, active disease surveillance and serologic testing of household contacts identified ALKHF in 28 persons in Najran, Saudi Arabia. For epidemiologic comparison, serologic testing of household and neighborhood controls identified 65 serologically negative persons. Among ALKHF patients, 11 were hospitalized and 17 had subclinical infection. Univariate analysis indicated that the following were associated with Alkhurma virus infection: contact with domestic animals, feeding and slaughtering animals, handling raw meat products, drinking unpasteurized milk, and being bitten by a tick. After multivariate modeling, the following associations remained significant: animal contact, neighboring farms, and tick bites.
• Subjects:
  Adolescent Adult Alkhurma Hemorrhagic Fever Alkhurma Virus Animals Antibodies, Viral Bites And Stings Case-Control Studies Child Child, Preschool Contact Tracing Disease Outbreaks Encephalitis, Tick-Borne Encephalitis Viruses, Tick-Borne Female Flavivirus Hemorrhagic Fever Hemorrhagic Fevers, Viral Humans Livestock Male Middle Aged Research Risk Factors RNA, Viral Saudi Arabia Seasons Seroepidemiologic Studies Tickborne Ticks Viruses Zoonoses

  More +
• Source:
  Emerg Infect Dis. 16(12):1882-1888.
• Document Type:
  Journal Article
• Volume:
  16
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6c3ccf85fb318459f93310f4296e4579ff2d24c52021d25aa285dd0662ac1c31
• Download URL:
  https://stacks.cdc.gov/view/cdc/24253/cdc_24253_DS1.pdf
• File Type:
  [PDF - 293.12 KB ]