Human Polyomavirus Related to African Green Monkey Lymphotropic Polyomavirus
Published Date:Aug 2011
Source:Emerg Infect Dis. 17(8):1364-1370.
African Green Monkey Lymphotrophic Virus
Aged, 80 And Over
Carcinoma, Merkel Cell
High-Throughput Nucleotide Sequencing
Merkel Cell Carcinoma Patients
Molecular Sequence Data
Polymerase Chain Reaction
Sequence Analysis, DNA
Tumor Virus Infections
Description:While studying the virome of the skin surface of a patient with a Merkel cell carcinoma (MCC) by using unbiased, high-throughput sequencing, we identified a human polyomavirus nearly identical to human polyomavirus 9, a virus recently reported in blood and urine of renal transplantion patients and closely related to the African green monkey lymphotropic polyomavirus. Specific PCR analysis further identified this virus in 2/8 patients with MCC but in only 1/111 controls without MCC. This virus was shed for ≥20 months by the MCC index patient and was on the skin of the spouse of the index patient. These results provide information on the viral ecology of human skin and raise new questions regarding the pathology of virus-associated skin disorders.
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