Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1708.110278
Personal Author:
Sauvage, Virginie ; Foulongne, Vincent ; Cheval, Justine ; Gouilh, Meriadeg Ar ; Pariente, Kevin ; ... More +
Sauvage, Virginie ; Foulongne, Vincent ; Cheval, Justine ; Gouilh, Meriadeg Ar ; Pariente, Kevin ; Dereure, Olivier ; Manuguerra, Jean Claude ; Richardson, Jennifer ; Lecuit, Marc ; Burguière, Ana ; Caro, Valérie ; Eloit, Marc Less -
Description:
While studying the virome of the skin surface of a patient with a Merkel cell carcinoma (MCC) by using unbiased, high-throughput sequencing, we identified a human polyomavirus nearly identical to human polyomavirus 9, a virus recently reported in blood and urine of renal transplantion patients and closely related to the African green monkey lymphotropic polyomavirus. Specific PCR analysis further identified this virus in 2/8 patients with MCC but in only 1/111 controls without MCC. This virus was shed for ≥20 months by the MCC index patient and was on the skin of the spouse of the index patient. These results provide information on the viral ecology of human skin and raise new questions regarding the pathology of virus-associated skin disorders.
Subjects:
[+]
Adult Aged Aged, 80 And Over Animals Carcinoma, Merkel Cell Cercopithecus Aethiops DNA, Viral Female High-Throughput Nucleotide Sequencing Humans Male Merkel Cells Middle Aged Molecular Sequence Data Phylogeny Polymerase Chain Reaction Polyomavirus Polyomavirus Infections Sequence Analysis, DNA Skin Skin Neoplasms Tumor Virus Infections Young Adult
Source:
Emerg Infect Dis. 17(8):1364-1370.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:9da8fdc6963155505e05d326078ab581fc33f77da82c192d382d1fbc9ed4a4ea
Download URL:
https://stacks.cdc.gov/view/cdc/24227/cdc_24227_DS1.pdf
File Type:

Supporting Files

• 	license.txt	txt
  	11-0278-F1.gif	gif
  	11-0278-F1.jpg	jpeg
  	11-0278-F2.gif	gif
  	11-0278-F2.jpg	jpeg
  	11-0278-F3.gif	gif
  	11-0278-F3.jpg	jpeg
  	11-0278_finalR.nxml	txt

More +