Human Polyomavirus Related to African Green Monkey Lymphotropic Polyomavirus

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Sauvage, Virginie ; Foulongne, Vincent ; Cheval, Justine ; Gouilh, Meriadeg Ar ; Pariente, Kevin ; Dereure, Olivier ; Manuguerra, Jean Claude ; Richardson, Jennifer ; Lecuit, Marc ; Burguière, Ana ; Caro, Valérie ; Eloit, Marc
• Description:
  While studying the virome of the skin surface of a patient with a Merkel cell carcinoma (MCC) by using unbiased, high-throughput sequencing, we identified a human polyomavirus nearly identical to human polyomavirus 9, a virus recently reported in blood and urine of renal transplantion patients and closely related to the African green monkey lymphotropic polyomavirus. Specific PCR analysis further identified this virus in 2/8 patients with MCC but in only 1/111 controls without MCC. This virus was shed for ≥20 months by the MCC index patient and was on the skin of the spouse of the index patient. These results provide information on the viral ecology of human skin and raise new questions regarding the pathology of virus-associated skin disorders.
• Subjects:
  Adult Aged Aged, 80 And Over Animals Carcinoma, Merkel Cell Cercopithecus Aethiops DNA, Viral Female High-Throughput Nucleotide Sequencing Humans Male Merkel Cells Middle Aged Molecular Sequence Data Phylogeny Polymerase Chain Reaction Polyomavirus Polyomavirus Infections Sequence Analysis, DNA Skin Skin Neoplasms Tumor Virus Infections Young Adult

  More +
• Source:
  Emerg Infect Dis. 17(8):1364-1370.
• Document Type:
  Journal Article
• Volume:
  17
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9da8fdc6963155505e05d326078ab581fc33f77da82c192d382d1fbc9ed4a4ea
• Download URL:
  https://stacks.cdc.gov/view/cdc/24227/cdc_24227_DS1.pdf
• File Type:
  [PDF - 531.43 KB ]