Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1708.110278
Personal Author:
Sauvage, Virginie ; Foulongne, Vincent ; Cheval, Justine ; Gouilh, Meriadeg Ar ; Pariente, Kevin ; ... More +
Sauvage, Virginie ; Foulongne, Vincent ; Cheval, Justine ; Gouilh, Meriadeg Ar ; Pariente, Kevin ; Dereure, Olivier ; Manuguerra, Jean Claude ; Richardson, Jennifer ; Lecuit, Marc ; Burguière, Ana ; Caro, Valérie ; Eloit, Marc Less -
Description:
While studying the virome of the skin surface of a patient with a Merkel cell carcinoma (MCC) by using unbiased, high-throughput sequencing, we identified a human polyomavirus nearly identical to human polyomavirus 9, a virus recently reported in blood and urine of renal transplantion patients and closely related to the African green monkey lymphotropic polyomavirus. Specific PCR analysis further identified this virus in 2/8 patients with MCC but in only 1/111 controls without MCC. This virus was shed for ≥20 months by the MCC index patient and was on the skin of the spouse of the index patient. These results provide information on the viral ecology of human skin and raise new questions regarding the pathology of virus-associated skin disorders.
Subject:
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Adult
African Green Monkey Lymphotrophic Virus
Aged
Aged, 80 And Over
Animals
Carcinoma, Merkel Cell
Cercopithecus Aethiops
DNA, Viral
Expedited
Female
High-throughput Nucleotide Sequencing
Humans
Infections
Male
Merkel Cell Carcinoma Patients
Merkel Cells
Middle Aged
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
Polyomavirus
Polyomavirus Infections
Research
Sequence Analysis, DNA
Shedding
Skin
Skin Neoplasms
Tumor Virus Infections
Viruses
Young Adult
Polyomavirus
Skin

Source:
Emerg Infect Dis. 17(8):1364-1370.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:9da8fdc6963155505e05d326078ab581fc33f77da82c192d382d1fbc9ed4a4ea
File Type:

Supporting Files

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