Cytogenetic study of workers exposed to ethylene oxide: analysis of the chromosomal aberration data and overall conclusions from the analyses of sister chromatid exchanges and chromosomal aberrations.

Details

• Personal Author:
  Ashworth L ; Carrano A ; Marlow D ; Meinhardt, Theodore J. ; Moore D ; Ashworth L ; Carrano A ; Marlow D ; Meinhardt, Theodore J. ; Moore D
• Description:
  A survey of the cytogenetic effects of exposure to ethylene-oxide (75218) was conducted. The cohort consisted of 43 workers in ethylene-oxide production units and 27 workers in a quality assurance laboratory who were exposed to ethylene-oxide and other chemicals. The comparisons consisted of 41 individuals having no exposure to chemicals. Circulating lymphocytes were isolated and assayed for chromosomal aberrations. Ethylene-oxide exposures in the production unit and quality assurance laboratory were measured. Median ethylene-oxide exposures ranged from 0.14 to 10.9 parts per million (ppm) in the laboratory and 0.19 to 1.0ppm in the production unit over a 5 year period. No significant increase in the incidence of chromosomal aberrations occurred in the production unit workers. Increases in the incidence of chromatid deletions and exchanges, total chromatid aberrations, percent of abnormal cells and total aberrations per cell occurred in the laboratory workers. The authors suggest that working in ethylene-oxide production units does not cause a statistically significant increase in chromosomal aberrations. Work in the quality assurance laboratory is associated with genotoxic effects; however, these cannot be attributed solely to ethylene-oxide due to the complex nature of the working environment. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no PDF
• Subjects:
  Biological Assay Cytology Genetics Laboratories Occupational Exposure Occupational Health Safety Workplace
• Keywords:
  NIOSH-Author; Bioassays; Genetic-factors; Occupational-exposure; Trace-analysis; Laboratory-workers; Laboratory-techniques; Workplace-studies; Cytology
• Document Type:
  Text
• Genre:
  Report ; Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  1-62
• NIOSHTIC Number:
  nn:00156828
• NTIS Accession Number:
  PB89145510
• Citation:
  NIOSH 1985 Dec; :1-62
• CAS Registry Number:
  Ethylene oxide (CAS RN 75-21-8) ; Ethylene oxide (CAS RN 75-21-8)
• Federal Fiscal Year:
  1986
• Peer Reviewed:
  False
• Source Full Name:
  Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, 62 pages, 46 references
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/242137/cdc_242137_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]