Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1708.101760
Personal Author:
Carr, Michael J. ; Kajon, Adriana E. ; Lu, Xiaoyan ; Dunford, Linda ; O’Reilly, Paul ; ... More +
Carr, Michael J. ; Kajon, Adriana E. ; Lu, Xiaoyan ; Dunford, Linda ; O’Reilly, Paul ; Holder, Paul ; De Gascun, Cillian F. ; Coughlan, Suzie ; Connell, Jeff ; Erdman, Dean D. ; Hall, William W. Less -
Description:
Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States in association with outbreaks of acute respiratory disease with high rates of illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009-July 31, 2010, and describe 9 cases of HAdV-14p1 infection with characteristic mutations in the fiber and E1A genes that are phylogenetically indistinguishable from the viruses previously detected in the United States. Three patients died; 2 were immunocompromised, and 1 was an immunocompetent adult. We propose that surveillance should be increased for HAdV-14p1 and recommend that this virus be considered in the differential diagnosis of sudden-onset acute respiratory disease, particularly fatal infections, for which an etiology is not clear.
Subject:
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Adenovirus E1A Proteins
Adenoviruses, Human
Adenovirus Infections, Human
Adult
Antibodies, Viral
Capsid Proteins
Cell Line, Tumor
Child, Preschool
CME
Communicable Diseases, Emerging
Female
Humans
Infant
Infant, Newborn
Ireland
Male
Middle Aged
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
Respiratory Tract Infections
Sequence Analysis, DNA
Serotyping
Survival Analysis
Virus Cultivation

Source:
Emerg Infect Dis. 17(8):1402-1408.
Document Type:
Journal Article
Place as Subject:
Europe
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:01a4de46b362b51ac39ce48d81a4741e96d78d81e58f498106b70c016bf794c0
File Type:

Supporting Files

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  	10-1760-F-2-2.jpg	jpeg
  	10-1760_finalRCME_PMC.nxml	txt
  	license.txt	txt

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