Deaths Associated with Human Adenovirus-14p1 Infections, Europe, 2009–2010
Published Date:Aug 2011
Source:Emerg Infect Dis. 17(8):1402-1408.
Keywords:Adenovirus E1A Proteins
Adenovirus Infections, Human
Adenovirus Serotype 14
Cell Line, Tumor
Communicable Diseases, Emerging
Molecular Sequence Data
Polymerase Chain Reaction
Respiratory Tract Infections
Restriction Enzyme Analysis
Sequence Analysis, DNA
Description:Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States in association with outbreaks of acute respiratory disease with high rates of illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009-July 31, 2010, and describe 9 cases of HAdV-14p1 infection with characteristic mutations in the fiber and E1A genes that are phylogenetically indistinguishable from the viruses previously detected in the United States. Three patients died; 2 were immunocompromised, and 1 was an immunocompetent adult. We propose that surveillance should be increased for HAdV-14p1 and recommend that this virus be considered in the differential diagnosis of sudden-onset acute respiratory disease, particularly fatal infections, for which an etiology is not clear.
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