Deaths Associated with Human Adenovirus-14p1 Infections, Europe, 2009–2010

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Carr, Michael J. ; Kajon, Adriana E. ; Lu, Xiaoyan ; Dunford, Linda ; O’Reilly, Paul ; Holder, Paul ; De Gascun, Cillian F. ; Coughlan, Suzie ; Connell, Jeff ; Erdman, Dean D. ; Hall, William W.
• Description:
  Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States in association with outbreaks of acute respiratory disease with high rates of illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009-July 31, 2010, and describe 9 cases of HAdV-14p1 infection with characteristic mutations in the fiber and E1A genes that are phylogenetically indistinguishable from the viruses previously detected in the United States. Three patients died; 2 were immunocompromised, and 1 was an immunocompetent adult. We propose that surveillance should be increased for HAdV-14p1 and recommend that this virus be considered in the differential diagnosis of sudden-onset acute respiratory disease, particularly fatal infections, for which an etiology is not clear.
• Subjects:
  Adenovirus E1A Proteins Adenoviruses, Human Adenovirus Infections, Human Adult Antibodies, Viral Capsid Proteins Cell Line, Tumor Child, Preschool CME Communicable Diseases, Emerging Female Humans Infant Infant, Newborn Ireland Male Middle Aged Molecular Sequence Data Phylogeny Polymerase Chain Reaction Respiratory Tract Infections Sequence Analysis, DNA Serotyping Survival Analysis Virus Cultivation

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• Source:
  Emerg Infect Dis. 17(8):1402-1408.
• Document Type:
  Journal Article
• Place as Subject:
  Europe
• Location:
  Europe
• Volume:
  17
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:01a4de46b362b51ac39ce48d81a4741e96d78d81e58f498106b70c016bf794c0
• Download URL:
  https://stacks.cdc.gov/view/cdc/24200/cdc_24200_DS1.pdf
• File Type:
  [PDF - 387.01 KB ]