Deaths Associated with Human Adenovirus-14p1 Infections, Europe, 2009–2010

Carr, Michael J.; Kajon, Adriana E.; Lu, Xiaoyan; Dunford, Linda; O’Reilly, Paul; Holder, Paul; De Gascun, Cillian F.; Coughlan, Suzie; Connell, Jeff; Erdman, Dean D.; Hall, William W.

doi:10.3201/eid1708.101760

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Deaths Associated with Human Adenovirus-14p1 Infections, Europe, 2009–2010

Published Date:

Aug 2011

Publisher's site:

http://dx.doi.org/10.3201/eid1708.101760 New Site Icon

Source:

Emerg Infect Dis. 17(8):1402-1408.

Language:

English

[PDF-387.01 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Carr, Michael J. ; Kajon, Adriana E. ; Lu, Xiaoyan ; Dunford, Linda ; O’Reilly, Paul ; ... More ▼

Description:

Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States in association with outbreaks of acute respiratory disease with high rates of illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009-July 31, 2010, and describe 9 cases of HAdV-14p1 infection with characteristic mutations in the fiber and E1A genes that are phylogenetically indistinguishable from the viruses previously detected in the United States. Three patients died; 2 were immunocompromised, and 1 was an immunocompetent adult. We propose that surveillance should be increased for HAdV-14p1 and recommend that this virus be considered in the differential diagnosis of sudden-onset acute respiratory disease, particularly fatal infections, for which an etiology is not clear.

Subject:

[+]

Document Type:

Journal Article

Place as Subject:

Europe

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

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