The biological effect of continuous inhalation exposure of 1,1,1- trichloroethane (methyl chloroform) on animals.

Details

• Personal Author:
  MacEwen JC ; Vernot EH
• Description:
  Studies were conducted to evaluate the effects of continuous exposure to 1,1,1-trichloroethane (71556) on hepatic morphology and function of various animals species, and to compare these effects with those produced by methylene-chloride (75092). The findings indicate that both compounds induce similar pathological alterations, except for different time courses of the effects and different degrees of recovery. A ten-fold greater atmospheric concentration of 1,1,1-trichloroethane is required to produce the minimal liver changes found at 100 ppm dichloromethane. This was a joint NIOSH, USAF, and NASA study. [Description provided by NIOSH]
• Subjects:
  Chlorine Compounds Hydrocarbons Liver Occupational Health Safety Solvents Toxicology
• Keywords:
  NIOSH-Contract; Chlorinated-ethanes; Chlorinated-hydrocarbons; Solvents; Degreasers; Industrial-chemicals; Hepatotoxicity; Liver-disorders; Toxicology; Chlorinated-methanes; Histopathology
• Document Type:
  Text
• Genre:
  Annual Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  81-90
• NIOSHTIC Number:
  nn:00055677
• Citation:
  Aerospace Medical Research Laboratory, Wright Patterson Air Force Base, Ohio, Toxic Hazards Research Unit, Annual Technical Report - 1974, AMRL-TR-74-78 1974 Jul; :81-90
• CAS Registry Number:
  1,1,1-Trichloroethane (CAS RN 71-55-6) ; Dichloromethane (CAS RN 75-09-2)
• Federal Fiscal Year:
  1974
• Peer Reviewed:
  False
• Source Full Name:
  Aerospace Medical Research Laboratory, Wright Patterson Air Force Base, Ohio, Toxic Hazards Research Unit, Annual Technical Report - 1974, AMRL-TR-74-78
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/241954/cdc_241954_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]