Tissue distribution of C-14-labeled ethylene dibromide in the guinea pig.

Details

• Personal Author:
  Coner WL ; Plotnick HB
• Description:
  A study was undertaken to determine the tissue distribution of uniformly radiocarbon-labeled ethylene-dibromide (106934) in guinea pigs following intraperitoneal administration. Organs containing the greatest concentration of radioactivity per unit weight (kidneys, liver, adrenals, pancreas, and spleen) were the same organs in which pathologic changes have been reported by other investigators, indicating a direct correlation between tissue levels and target organ toxicity. The principal route of excretion was via the kidneys, 66 percent of the dose appearing in the urine within 72 hours of administration. Fecal excretion for the 72 hour period was relatively insignificant, representing less than 3 percent of the dose. [Description provided by NIOSH]
• Subjects:
  Bromine Compounds Hydrocarbons Occupational Health Radiation Safety Toxicology
• Keywords:
  Brominated-hydrocarbons; Brominated-ethylenes; Fumigants; Radioactive-tracer-analysis; Toxicology
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-8
• NIOSHTIC Number:
  nn:00052579
• Citation:
  NIOSH 1975; :1-8
• CAS Registry Number:
  1,2-Dibromoethane (CAS RN 106-93-4)
• Federal Fiscal Year:
  1975
• Peer Reviewed:
  False
• Source Full Name:
  NIOSH, Center for Disease Control, Cincinnati, Ohio, 8 pages, 9 references
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/241934/cdc_241934_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]