Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1708.101528
Personal Author:
Ouattara, Louise A. ; Barin, Francis ; Barthez, Marie Anne ; Bonnaud, Bertrand ; Roingeard, Philippe ; ... More +
Ouattara, Louise A. ; Barin, Francis ; Barthez, Marie Anne ; Bonnaud, Bertrand ; Roingeard, Philippe ; Goudeau, Alain ; Castelnau, Pierre ; Vernet, Guy ; Paranhos-Baccalà, Gláucia ; Komurian-Pradel, Florence ; Less -
Description:
For many encephalitis cases, the cause remains unidentified. After 2 children (from the same family) received a diagnosis of acute necrotizing encephalopathy at Centre Hospitalier Universitaire (Tours, France), we attempted to identify the etiologic agent. Because clinical samples from the 2 patients were negative for all pathogens tested, urine and throat swab specimens were added to epithelial cells, and virus isolates detected were characterized by molecular analysis and electron microscopy. We identified a novel reovirus strain (serotype 2), MRV2Tou05, which seems to be closely related to porcine and human strains. A specific antibody response directed against this new reovirus strain was observed in convalescent-phase serum specimens from the patients, whereas no response was observed in 38 serum specimens from 38 healthy adults. This novel reovirus is a new etiologic agent of encephalitis.
Subject:
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Adult
Animals
Antibodies, Viral
Cell Line
Cercopithecus Aethiops
Child
Encephalitis
Encephalitis, Viral
Female
France
Hospitals, University
Humans
Infant
Leukoencephalitis, Acute Hemorrhagic
Male
Mammalian Orthoreovirus 2
Orthoreovirus, Mammalian
Phylogeny
Reassortant Viruses
Reoviridae Infections
Research
Sequence Analysis, DNA
Serotyping
Vero Cells
Viruses

Source:
Emerg Infect Dis. 17(8):1436-1444.
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:2cae04d9e0c45cb210234036dd2e48a94bce967582227caf607e858830bf74c9
File Type:

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