Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Lim, Wei-Yen; Chen, Cynthia H.J.; Ma, Yi; Chen, Mark I.C.; Lee, Vernon J.M.; ... More +
Lim, Wei-Yen; Chen, Cynthia H.J.; Ma, Yi; Chen, Mark I.C.; Lee, Vernon J.M.; Cook, Alex R.; Tan, Linda W.L.; Tabo, Norberto Flores; Barr, Ian; Cui, Lin; Lin, Raymond T.P.; Leo, Yee Sin; Chia, Kee Seng; Less -
Description:
A total of 828 community-dwelling adults were studied during the course of the pandemic (H1N1) 2009 outbreak in Singapore during June-September 2009. Baseline blood samples were obtained before the outbreak, and 2 additional samples were obtained during follow-up. Seroconversion was defined as a >4-fold increase in antibody titers to pandemic (H1N1) 2009, determined by using hemagglutination inhibition. Men were more likely than women to seroconvert (mean adjusted hazards ratio [HR] 2.23, mean 95% confidence interval [CI] 1.26-3.93); Malays were more likely than Chinese to seroconvert (HR 2.67, 95% CI 1.04-6.91). Travel outside Singapore during the study period was associated with seroconversion (HR 1.76, 95% CI 1.11-2.78) as was use of public transport (HR 1.81, 95% CI 1.05-3.09). High baseline antibody titers were associated with reduced seroconversion. This study suggests possible areas for intervention to reduce transmission during future influenza outbreaks.
Subject:
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Adolescent
Adult
Antibodies, Viral
Child
Child, Preschool
Cohort Studies
Disease Outbreaks
Female
Hemagglutination Inhibition Tests
Humans
Influenza, Human
Influenza A Virus, H1N1 Subtype
Male
Pandemics
Risk Factors
Young Adult

Source:
Emerg Infect Dis. 17(8):1455-1462.;
Document Type:
Journal Article;
Place as Subject:
Singapore;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:bc33da4195999327d927284a831095c724cbdb996e83dbd566667f2d341d6e29
File Type:

Supporting Files

• 	license.txt	txt
  	10-1270-F-2-1.gif	gif
  	10-1270-F-2-1.jpg	jpeg
  	10-1270-F-2-2.gif	gif
  	10-1270-F-2-2.jpg	jpeg
  	10-1270-Techapp_3p.pdf	pdf
  	10-1270_finalRCME_PMC.nxml	txt

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