Risk Factors for Pandemic (H1N1) 2009 Seroconversion among Adults, Singapore, 2009

Lim, Wei-Yen; Chen, Cynthia H.J.; Ma, Yi; Chen, Mark I.C.; Lee, Vernon J.M.; Cook, Alex R.; Tan, Linda W.L.; Tabo, Norberto Flores; Barr, Ian; Cui, Lin; Lin, Raymond T.P.; Leo, Yee Sin; Chia, Kee Seng

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Risk Factors for Pandemic (H1N1) 2009 Seroconversion among Adults, Singapore, 2009

Published Date:

Aug 2011

Source:

Emerg Infect Dis. 17(8):1455-1462.

[PDF-355.57 KB]

Details:

Personal Authors:

Lim, Wei-Yen ; Chen, Cynthia H.J. ; Ma, Yi ; Chen, Mark I.C. ; Lee, Vernon J.M. ; ... More ▼

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Description:

A total of 828 community-dwelling adults were studied during the course of the pandemic (H1N1) 2009 outbreak in Singapore during June-September 2009. Baseline blood samples were obtained before the outbreak, and 2 additional samples were obtained during follow-up. Seroconversion was defined as a >4-fold increase in antibody titers to pandemic (H1N1) 2009, determined by using hemagglutination inhibition. Men were more likely than women to seroconvert (mean adjusted hazards ratio [HR] 2.23, mean 95% confidence interval [CI] 1.26-3.93); Malays were more likely than Chinese to seroconvert (HR 2.67, 95% CI 1.04-6.91). Travel outside Singapore during the study period was associated with seroconversion (HR 1.76, 95% CI 1.11-2.78) as was use of public transport (HR 1.81, 95% CI 1.05-3.09). High baseline antibody titers were associated with reduced seroconversion. This study suggests possible areas for intervention to reduce transmission during future influenza outbreaks.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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