Development of biologic standards for trichloroethylene.

Details

• Personal Author:
  Forster HV ; Hake CL ; Lebrun AJ ; Newton PE ; Peterson JE ; Soto RJ ; Stewart RD
• Description:
  Male and female human beings are exposed to 20, 100, and 200 parts per million (ppm) trichloroethylene (TCE) (79016) vapor for five consecutive days, to establish the basis for a biologic test through expired breath data, and to study TCE's effects on cognitive and behavioral tasks. Post-exposure TCE breath decay curves are constructed from the data obtained from the volunteers exposed to the three vapor concentrations for three different intervals of time. Exposure to TCE, 100 ppm or greater for 7.5 hours daily produces an alteration in the visual evoked response (VER) of one of three males and all female subjects. Decrements in task performance are observed in two tests: Flanagan coordination and the random number inspection. No dose-response effect is observed. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Hydrocarbons Nervous System Diseases Occupational Health Safety Solvents
• Keywords:
  NIOSH-Contract; Contract-099-72-0084; Chlorinated-hydrocarbons; Toxic-substances; Organic-solvents; Analytical-methods; Safety-standards; Threshold-limit-values; Human-performance; Nervous-system-disorders
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  81-91
• NIOSHTIC Number:
  nn:00047831
• Citation:
  Behavioral Toxicology: Early Detection of Occupational Hazards. Xintaras C, Johnson BL, De Groot I, eds., Washington, DC: National Institute for Occupational Safety and Health, (NIOSH) 74-126, 1974 Jan; :81-91
• CAS Registry Number:
  Trichloroethylene (CAS RN 79-01-6)
• Editor(s):
  Xintaras C; Johnson BL; De Groot I
• Federal Fiscal Year:
  1974
• Performing Organization:
  The Medical College of Wisconsin, Department of Environmental Medicine
• Peer Reviewed:
  False
• Source Full Name:
  Behavioral Toxicology: Early Detection of Occupational Hazards
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/241800/cdc_241800_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]