Astrovirus Encephalitis in Boy with X-linked Agammaglobulinemia

Quan, Phenix-Lan; Wagner, Thor A.; Briese, Thomas; Torgerson, Troy R.; Hornig, Mady; Tashmukhamedova, Alla; Firth, Cadhla; Palacios, Gustavo; Baisre-De-Leon, Ada; Paddock, Christopher D.; Hutchison, Stephen K.; Egholm, Michael; Zaki, Sherif R.; Goldman, James E.; Ochs, Hans D.; Lipkin, W. Ian

doi:10.3201/eid1606.091536

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Astrovirus Encephalitis in Boy with X-linked Agammaglobulinemia

Published Date:

Jun 2010

Publisher's site:

http://dx.doi.org/10.3201/eid1606.091536 New Site Icon

Source:

Emerg Infect Dis. 16(6):918-925.

[PDF - 406.86 KB]

Details:

Personal Authors:

Quan, Phenix-Lan ; Wagner, Thor A. ; Briese, Thomas ; Torgerson, Troy R. ; Hornig, Mady ; ... More ▼

Keywords:

[+]

Description:

Encephalitis is a major cause of death worldwide. Although >100 pathogens have been identified as causative agents, the pathogen is not determined for up to 75% of cases. This diagnostic failure impedes effective treatment and underscores the need for better tools and new approaches for detecting novel pathogens or determining new manifestations of known pathogens. Although astroviruses are commonly associated with gastroenteritis, they have not been associated with central nervous system disease. Using unbiased pyrosequencing, we detected an astrovirus as the causative agent for encephalitis in a 15-year-old boy with agammaglobulinemia; several laboratories had failed to identify the agent. Our findings expand the spectrum of causative agents associated with encephalitis and highlight unbiased molecular technology as a valuable tool for differential diagnosis of unexplained disease.

Document Type:

Journal Article

Collection(s):

CDC Public Access
Emerging Infectious Diseases

Funding:

AI070411/AI/NIAID NIH HHS/United States
AI57158/AI/NIAID NIH HHS/United States
EY017404-02/EY/NEI NIH HHS/United States
R24 EY017404/EY/NEI NIH HHS/United States
U01 AI070411/AI/NIAID NIH HHS/United States
U54 AI057158/AI/NIAID NIH HHS/United States

Supporting Files:

09-1536-F1.gif	image/gif
09-1536-F1.jpg	image/jpeg
09-1536-F2.gif	image/gif
09-1536-F2.jpg	image/jpeg
09-1536-F3.gif	image/gif
09-1536-F3.jpg	image/jpeg
09-1536-F4.gif	image/gif
09-1536-F4.jpg	image/jpeg
09-1536.nxml	text/plain
license.txt	text/plain

No Related Documents.

You May Also Like:

MLB1 Astrovirus in Children with Gastroenteritis, Italy

Personal Author:

Medici, Maria Cristina; Tummolo, Fabio; Calderaro, Adriana; Elia, Gabriella; Banyai, Krisztiàn; De Conto, Flora; Arcangeletti, Maria Cristina; Chezzi, Carlo; Buonavoglia, Canio; Martella, Vito;

Published:

Jan 2014

Source:

Emerg Infect Dis. 20(1):169-170.

File Type:

[PDF - 314.94 KB]
Divergent Astrovirus Associated with Neurologic Disease in Cattle

Personal Author:

Li, Linlin; Diab, Santiago; McGraw, Sabrina; Barr, Bradd; Traslavina, Ryan; Higgins, Robert; Talbot, Tom; Blanchard, Pat; Rimoldi, Guillermo; Fahsbender, Elizabeth; Page, Brady; Phan, Tung Gia; Wang, Chunlin; Deng, Xutao; Pesavento, Patricia; Delwart, Eric;

Published:

2013

Source:

Emerg Infect Dis. 19(9):1385-1392.

Description:

Using viral metagenomics of brain tissue from a young adult crossbreed steer with acute onset of neurologic disease, we sequenced the complete genome of a novel astrovirus (BoAstV-NeuroS1) that was phylogenetically related to an ovine astrovirus. In ...

File Type:

[PDF - 586.59 KB]
Population-Based Incidence Rates of Diarrheal Disease Associated with Norovirus, Sapovirus, and Astrovirus in Kenya

Personal Author:

Shioda, Kayoko; Cosmas, Leonard; Audi, Allan; Gregoricus, Nicole; Vinjé, Jan; Parashar, Umesh D.; Montgomery, Joel M.; Feikin, Daniel R.; Breiman, Robert F.; Hall, Aron J.;

Published:

Apr 26 2016

Source:

PLoS One. 11(4).

Description:

Background : Diarrheal diseases remain a major cause of mortality in Africa and worldwide. While the burden of rotavirus is well described, population-based rates of disease caused by norovirus, sapovirus, and astrovirus are lacking, particularly in ...

File Type:

[PDF - 3.17 MB]
The stability of hexacosanoyl lysophosphatidylcholine in dried-blood spot quality control materials for X-linked adrenoleukodystrophy newborn screening

Personal Author:

Haynes, Christopher A.; De Jesús, Víctor R.;

Published:

Oct 12 2014

Source:

Clin Biochem. 48(1-2):8-10.

Description:

Objectives : Newborn screening for X-linked adrenoleukodystrophy utilizes tandem mass spectrometry to analyze dried-blood spot specimens. Quality control materials (dried-blood spots enriched with hexacosanoyl lysophosphatidylcholine) were prepared a...

File Type:

[PDF - 83.55 KB]
Astrovirus MLB2 Viremia in Febrile Child

Personal Author:

Holtz, Lori R.; Wylie, Kristine M.; Sodergren, Erica; Jiang, Yanfang; Franz, Carl J.; Weinstock, George M.; Storch, Gregory A.; Wang, David;

Published:

Nov 2011

Source:

Emerg Infect Dis. 17(11):2050-2052.

Description:

Astroviruses cause diarrhea, but it is not known whether they circulate in human plasma. Astrovirus MLB2 was recently discovered in diarrhea samples from children. We detected MLB2 in the plasma of a febrile child, which suggests that MLB2 has broade...

File Type:

[PDF - 237.64 KB]