Astrovirus Encephalitis in Boy with X-linked Agammaglobulinemia
Published Date:Jun 2010
Source:Emerg Infect Dis. 16(6):918-925.
Genetic Diseases, X-Linked
Sequence Analysis, RNA
Unbiased High-throughput Sequencing
Funding:AI070411/AI/NIAID NIH HHS/United States
AI57158/AI/NIAID NIH HHS/United States
EY017404-02/EY/NEI NIH HHS/United States
R24 EY017404/EY/NEI NIH HHS/United States
U01 AI070411/AI/NIAID NIH HHS/United States
U54 AI057158/AI/NIAID NIH HHS/United States
Description:Encephalitis is a major cause of death worldwide. Although >100 pathogens have been identified as causative agents, the pathogen is not determined for up to 75% of cases. This diagnostic failure impedes effective treatment and underscores the need for better tools and new approaches for detecting novel pathogens or determining new manifestations of known pathogens. Although astroviruses are commonly associated with gastroenteritis, they have not been associated with central nervous system disease. Using unbiased pyrosequencing, we detected an astrovirus as the causative agent for encephalitis in a 15-year-old boy with agammaglobulinemia; several laboratories had failed to identify the agent. Our findings expand the spectrum of causative agents associated with encephalitis and highlight unbiased molecular technology as a valuable tool for differential diagnosis of unexplained disease.
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