Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1606.091536
Personal Author:
Quan, Phenix-Lan ; Wagner, Thor A. ; Briese, Thomas ; Torgerson, Troy R. ; Hornig, Mady ; ... More +
Quan, Phenix-Lan ; Wagner, Thor A. ; Briese, Thomas ; Torgerson, Troy R. ; Hornig, Mady ; Tashmukhamedova, Alla ; Firth, Cadhla ; Palacios, Gustavo ; Baisre-De-Leon, Ada ; Paddock, Christopher D. ; Hutchison, Stephen K. ; Egholm, Michael ; Zaki, Sherif R. ; Goldman, James E. ; Ochs, Hans D. ; Lipkin, W. Ian ; Less -
Description:
Encephalitis is a major cause of death worldwide. Although >100 pathogens have been identified as causative agents, the pathogen is not determined for up to 75% of cases. This diagnostic failure impedes effective treatment and underscores the need for better tools and new approaches for detecting novel pathogens or determining new manifestations of known pathogens. Although astroviruses are commonly associated with gastroenteritis, they have not been associated with central nervous system disease. Using unbiased pyrosequencing, we detected an astrovirus as the causative agent for encephalitis in a 15-year-old boy with agammaglobulinemia; several laboratories had failed to identify the agent. Our findings expand the spectrum of causative agents associated with encephalitis and highlight unbiased molecular technology as a valuable tool for differential diagnosis of unexplained disease.
Subject:
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Adolescent
Agammaglobulinemia
Astroviridae Infections
Capsid Proteins
Encephalitis, Viral
Fatal Outcome
Frontal Lobe
Genetic Diseases, X-Linked
Humans
Immunohistochemistry
Male
Mamastrovirus
Phylogeny
Research
RNA, Viral
Sequence Analysis, RNA

Source:
Emerg Infect Dis. 16(6):918-925. ;
Document Type:
Journal Article ;
Funding:
AI070411/AI/NIAID NIH HHS/United States ; AI57158/AI/NIAID NIH HHS/United States ; EY017404-02/EY/NEI NIH HHS/United States ; R24 EY017404/EY/NEI NIH HHS/United States ; U01 AI070411/AI/NIAID NIH HHS/United States ; ... More +
AI070411/AI/NIAID NIH HHS/United States ; AI57158/AI/NIAID NIH HHS/United States ; EY017404-02/EY/NEI NIH HHS/United States ; R24 EY017404/EY/NEI NIH HHS/United States ; U01 AI070411/AI/NIAID NIH HHS/United States ; U54 AI057158/AI/NIAID NIH HHS/United States ; Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:78ccb5b9eb2afbe06437c4dc5d731cccb790687bc66a754b7ab083a6e52e9121
File Type:

Supporting Files

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