Astrovirus Encephalitis in Boy with X-linked Agammaglobulinemia

Quan, Phenix-Lan; Wagner, Thor A.; Briese, Thomas; Torgerson, Troy R.; Hornig, Mady; Tashmukhamedova, Alla; Firth, Cadhla; Palacios, Gustavo; Baisre-De-Leon, Ada; Paddock, Christopher D.; Hutchison, Stephen K.; Egholm, Michael; Zaki, Sherif R.; Goldman, James E.; Ochs, Hans D.; Lipkin, W. Ian

doi:10.3201/eid1606.091536

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Astrovirus Encephalitis in Boy with X-linked Agammaglobulinemia

Published Date:

Jun 2010

Publisher's site:

http://dx.doi.org/10.3201/eid1606.091536 New Site Icon

Source:

Emerg Infect Dis. 16(6):918-925.

[PDF-406.86 KB]

Details:

Personal Authors:

Quan, Phenix-Lan ; Wagner, Thor A. ; Briese, Thomas ; Torgerson, Troy R. ; Hornig, Mady ; ... More ▼

Keywords:

[+]

Description:

Encephalitis is a major cause of death worldwide. Although >100 pathogens have been identified as causative agents, the pathogen is not determined for up to 75% of cases. This diagnostic failure impedes effective treatment and underscores the need for better tools and new approaches for detecting novel pathogens or determining new manifestations of known pathogens. Although astroviruses are commonly associated with gastroenteritis, they have not been associated with central nervous system disease. Using unbiased pyrosequencing, we detected an astrovirus as the causative agent for encephalitis in a 15-year-old boy with agammaglobulinemia; several laboratories had failed to identify the agent. Our findings expand the spectrum of causative agents associated with encephalitis and highlight unbiased molecular technology as a valuable tool for differential diagnosis of unexplained disease.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases
CDC Public Access

Funding:

AI070411/AI/NIAID NIH HHS/United States
AI57158/AI/NIAID NIH HHS/United States
EY017404-02/EY/NEI NIH HHS/United States
R24 EY017404/EY/NEI NIH HHS/United States
U01 AI070411/AI/NIAID NIH HHS/United States
U54 AI057158/AI/NIAID NIH HHS/United States

Main Document Checksum:

[+]

Supporting Files:

	09-1536.nxml	text/plain
	license.txt	text/plain
	09-1536-F1.gif	image/gif
	09-1536-F1.jpg	image/jpeg
	09-1536-F2.gif	image/gif
	09-1536-F2.jpg	image/jpeg
	09-1536-F3.gif	image/gif
	09-1536-F3.jpg	image/jpeg
	09-1536-F4.gif	image/gif
	09-1536-F4.jpg	image/jpeg

No Related Documents.

You May Also Like:

Divergent Astrovirus Associated with Neurologic Disease in Cattle

Personal Author:

Li, Linlin; Diab, Santiago; McGraw, Sabrina; Barr, Bradd; Traslavina, Ryan; Higgins, Robert; Talbot, Tom; Blanchard, Pat; Rimoldi, Guillermo; Fahsbender, Elizabeth; Page, Brady; Phan, Tung Gia; Wang, Chunlin; Deng, Xutao; Pesavento, Patricia; Delwart, Eric;

Published:

2013

Source:

Emerg Infect Dis. 19(9):1385-1392.

Description:

Using viral metagenomics of brain tissue from a young adult crossbreed steer with acute onset of neurologic disease, we sequenced the complete genome of a novel astrovirus (BoAstV-NeuroS1) that was phylogenetically related to an ovine astrovirus. In ...

File Type:

[PDF - 586.59 KB]
MLB1 Astrovirus in Children with Gastroenteritis, Italy

Personal Author:

Medici, Maria Cristina; Tummolo, Fabio; Calderaro, Adriana; Elia, Gabriella; Banyai, Krisztiàn; De Conto, Flora; Arcangeletti, Maria Cristina; Chezzi, Carlo; Buonavoglia, Canio; Martella, Vito;

Published:

Jan 2014

Source:

Emerg Infect Dis. 20(1):169-170.

File Type:

[PDF - 314.94 KB]
Astrovirus MLB2 Viremia in Febrile Child

Personal Author:

Holtz, Lori R.; Wylie, Kristine M.; Sodergren, Erica; Jiang, Yanfang; Franz, Carl J.; Weinstock, George M.; Storch, Gregory A.; Wang, David;

Published:

Nov 2011

Source:

Emerg Infect Dis. 17(11):2050-2052.

Description:

Astroviruses cause diarrhea, but it is not known whether they circulate in human plasma. Astrovirus MLB2 was recently discovered in diarrhea samples from children. We detected MLB2 in the plasma of a febrile child, which suggests that MLB2 has broade...

File Type:

[PDF - 237.64 KB]
Human Parvovirus 4 as Potential Cause of Encephalitis in Children, India

Personal Author:

Benjamin, Laura A.; Lewthwaite, Penny; Vasanthapuram, Ravi; Zhao, Guoyan; Sharp, Colin; Simmonds, Peter; Wang, David; Solomon, Tom;

Published:

Aug 2011

Source:

Emerg Infect Dis. 17(8):1484-1487.

Description:

To investigate whether uncharacterized infectious agents were associated with neurologic disease, we analyzed cerebrospinal fluid specimens from 12 children with acute central nervous system infection. A high-throughput pyrosequencing screen detected...

File Type:

[PDF - 367.36 KB]
Use of Staged Molecular Analysis to Determine Causes of Unexplained Central Nervous System Infections

Personal Author:

Hsu, Chien-Chin; Tokarz, Rafal; Briese, Thomas; Tsai, Hung-Chin; Quan, Phenix-Lan; Lipkin, W. Ian;

Published:

2013

Source:

Emerg Infect Dis. 19(9):1470-1477.

Description:

No agent is implicated in most central nervous system (CNS) infections. To investigate cerebrospinal fluid samples from patients with CNS infections of unknown cause in 1 hospital in Taiwan, we used a staged molecular approach, incorporating techniqu...

File Type:

[PDF - 538.75 KB]