The biological action of the coumarins.

Details

• Personal Author:
  Scheel, Lester D.
• Description:
  The biologic activity of coumarin (91645) compounds is discussed. Uses of these substances in food, perfumes, and cosmetics is reviewed, and data on metabolic pathways is summarized. The results of numerous investigations on the toxic effects of coumarin, hydroxycoumarins, 4-hydroxycoumarin (1076386), and psoralens are discussed, along with studies of the formation and concentration of these compounds in mold and plant tissues. Biochemical and metabolic theories of coumarin formation in molds are evaluated. The author suggests that a symbiotic relationship exists between plant tissue and coumarin producing molds. These compounds appear to have a great potential for beneficial use; however, a better understanding of their mechanisms of action is needed. [Description provided by NIOSH]
• Subjects:
  Biochemistry Chemistry Cosmetics Energy Metabolism Food Additives Occupational Health Safety
• Keywords:
  NIOSH-Author; Chemical-kinetics; Biological-effects; Biochemical-analysis; Metabolic-study; Pharmacodynamics; Food-additives; Chemical-properties; Cosmetics
• ISBN:
  9780120465088
• Publisher:
  Academic Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  47-66
• Volume:
  8
• NIOSHTIC Number:
  nn:00128089
• Citation:
  Microbial toxins, volume 8: fungal toxins. Kadis S, Montie TC, Weinbaum G, Ciegler A, Ajl SJ, eds. New York: Academic Press, 1972 Jul; 8:47-66
• CAS Registry Number:
  4-Hydroxycoumarin (CAS RN 1076-38-6) ; Coumarin (CAS RN 91-64-5)
• Editor(s):
  Kadis S; Montie TC; Weinbaum G; Ciegler A; Ajl SJ
• Federal Fiscal Year:
  1972
• Peer Reviewed:
  False
• Source Full Name:
  Microbial toxins, volume 8: fungal toxins
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/241570/cdc_241570_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]