Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Bitar, Dounia ; Lortholary, Olivier ; Le Strat, Yann ; Nicolau, Javier ; Coignard, Bruno ; ... More +
Bitar, Dounia ; Lortholary, Olivier ; Le Strat, Yann ; Nicolau, Javier ; Coignard, Bruno ; Tattevin, Pierre ; Che, Didier ; Dromer, Françoise Less -
Description:
To determine the epidemiology and trends of invasive fungal infections (IFIs) in France, we analyzed incidence, risk factors, and in-hospital death rates related to the most frequent IFIs registered in the national hospital discharge database during 2001-2010. The identified 35,876 IFI cases included candidemia (43.4%), Pneumocystis jirovecii pneumonia (26.1%), invasive aspergillosis (IA, 23.9%), cryptococcosis (5.2%), and mucormycosis (1.5%). The overall incidence was 5.9/100,000 cases/year and the mortality rate was 27.6%; both increased over the period (+1.5%, +2.9%/year, respectively). Incidences substantially increased for candidemia, IA, and mucormycosis. Pneumocystis jirovecii pneumonia incidence decreased among AIDS patients (-14.3%/year) but increased in non-HIV-infected patients (+13.3%/year). Candidemia and IA incidence was increased among patients with hematologic malignancies (>+4%/year) and those with chronic renal failure (>+10%/year). In-hospital deaths substantially increased in some groups, e.g., in those with hematologic malignancies. IFIs occur among a broad spectrum of non-HIV-infected patients and should be a major public health priority.
Subjects:
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Aspergillosis Candidemia Cryptococcosis Invasive Mycosis Mucormycosis Pneumocystis Jirovecii Research
Source:
Emerg Infect Dis. 20(7):1163-1169.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:a2f19cb73692e35757c7ede56dbd33ecadcf9c35c55f7dc2e17cb77481b9e783
Download URL:
https://stacks.cdc.gov/view/cdc/24117/cdc_24117_DS1.pdf
File Type:

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  	14-0087-Techapp-s2.pdf	pdf
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