Nutritional Factors and Preservation of C-Peptide in Youth With Recently Diagnosed Type 1 Diabetes

Details

• Alternative Title:
  Diabetes Care
• Personal Author:
  Mayer-Davis, Elizabeth J. ; Dabelea, Dana ; Crandell, Jamie L. ; Crume, Tessa ; D’Agostino, Ralph B. ; Dolan, Lawrence ; King, Irena B. ; Lawrence, Jean M. ; Norris, Jill M. ; Pihoker, Catherine ; The, Natalie
• Description:
  OBJECTIVE
  
  To test the novel hypothesis that nutritional factors previously associated with type 1 diabetes etiology or with insulin secretion are prospectively associated with fasting C-peptide (FCP) concentration among youth recently diagnosed with type 1 diabetes.
  
  RESEARCH DESIGN AND METHODS
  
  Included were 1,316 youth with autoantibody-positive type 1 diabetes who participated in the SEARCH for Diabetes in Youth study (baseline disease duration, 9.9 months; SD, 6.3). Nutritional exposures included breastfeeding and age at introduction of complementary foods, baseline plasma long-chain omega-3 fatty acids including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), vitamin D, vitamin E, and, from a baseline food frequency questionnaire, estimated intake of the branched-chain amino acid leucine and total carbohydrate. Multiple linear regression models were conducted to relate each nutritional factor to baseline FCP adjusted for demographics, disease-related factors, and other confounders. Prospective analyses included the subset of participants with preserved β-cell function at baseline (baseline FCP ≥0.23 ng/mL) with additional adjustment for baseline FCP and time (mean follow-up, 24.3 months; SD, 8.2; n = 656). FCP concentration was analyzed as log(FCP).
  
  RESULTS
  
  In adjusted prospective analyses, baseline EPA (P = 0.02), EPA plus DHA (P = 0.03), and leucine (P = 0.03) were each associated positively and significantly with FCP at follow-up. Vitamin D was unexpectedly inversely associated with FCP (P = 0.002).
  
  CONCLUSIONS
  
  Increased intake of branched-chain amino acids and long-chain omega-3 fatty acids may support preservation of β-cell function. This represents a new direction for research to improve prognosis for type 1 diabetes.
  
  
• Subjects:
  Adolescent Amino Acids, Branched-Chain C-Peptide Child Diabetes Mellitus, Type 1 Docosahexaenoic Acids Eicosapentaenoic Acid Fasting Fatty Acids, Omega-3 Female Humans Male Nutritional Status Prospective Studies

  More +
• Source:
  Diabetes Care. 2013; 36(7):1842-1850.
• Pubmed ID:
  23801797
• Pubmed Central ID:
  PMC3687285
• Document Type:
  Journal Article
• Funding:
  1U18DP002709/DP/NCCDPHP CDC HHS/United States ; 1UL1RR026314-01/RR/NCRR NIH HHS/United States ; 200-2010-35171/PHS HHS/United States ; DK056350/DK/NIDDK NIH HHS/United States ; DP-05-069/DP/NCCDPHP CDC HHS/United States ; DP-10-001/DP/NCCDPHP CDC HHS/United States ; M01 RR00069/RR/NCRR NIH HHS/United States ; M01RR00037/RR/NCRR NIH HHS/United States ; P30 DK57516/DK/NIDDK NIH HHS/United States ; R01 DK077949/DK/NIDDK NIH HHS/United States ; U01 DP000244/DP/NCCDPHP CDC HHS/United States ; U01 DP000245/DP/NCCDPHP CDC HHS/United States ; U01 DP000246/DP/NCCDPHP CDC HHS/United States ; U01 DP000247/DP/NCCDPHP CDC HHS/United States ; U01 DP000248/DP/NCCDPHP CDC HHS/United States ; U01 DP000250/DP/NCCDPHP CDC HHS/United States ; U01 DP000254/DP/NCCDPHP CDC HHS/United States ; U18DP000247-06A1/DP/NCCDPHP CDC HHS/United States ; U18DP002708-01/DP/NCCDPHP CDC HHS/United States ; U18DP002710-01/DP/NCCDPHP CDC HHS/United States ; U18DP002714/DP/NCCDPHP CDC HHS/United States ; U48/CCU419249/PHS HHS/United States ; U48/CCU519239/PHS HHS/United States ; U48/CCU819241-3/PHS HHS/United States ; U48/CCU919219/PHS HHS/United States ; U58/CCU019235-4/PHS HHS/United States ; U58CCU919256/PHS HHS/United States ; UL1 TR000077/TR/NCATS NIH HHS/United States ; UL1RR029882/RR/NCRR NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  36
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1fa0ab8b6410f02d3dece47fb8fe8a5f1c19721c292cf1f50b9b4d7ea37c2101
• Download URL:
  https://stacks.cdc.gov/view/cdc/24004/cdc_24004_DS1.pdf
• File Type:
  [PDF - 147.54 KB ]