Phase transitions and size scaling of membrane-less organelles

Details

• Alternative Title:
  J Cell Biol
• Personal Author:
  Brangwynne, Clifford P.
• Description:
  The coordinated growth of cells and their organelles is a fundamental and poorly understood problem, with implications for processes ranging from embryonic development to oncogenesis. Recent experiments have shed light on the cell size-dependent assembly of membrane-less cytoplasmic and nucleoplasmic structures, including ribonucleoprotein (RNP) granules and other intracellular bodies. Many of these structures behave as condensed liquid-like phases of the cytoplasm/nucleoplasm. The phase transitions that appear to govern their assembly exhibit an intrinsic dependence on cell size, and may explain the size scaling reported for a number of structures. This size scaling could, in turn, play a role in cell growth and size control.
• Subjects:
  Animals Cell Enlargement Cell Size Centrosome Gravitation Intracellular Membranes Intracellular Space Organelles Reviews Ribonucleoproteins Spindle Apparatus Xenopus Laevis

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• Source:
  J Cell Biol. 2013; 203(6):875-881.
• Document Type:
  Journal Article
• Funding:
  DP2GM105437-01/DP/NCCDPHP CDC HHS/United States
• Volume:
  203
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6f49d5515b5ccc540fd7703601a5d841a32a75f6c420b8a28b7b6ad9f95d68af
• Download URL:
  https://stacks.cdc.gov/view/cdc/23944/cdc_23944_DS1.pdf
• File Type:
  [PDF - 1.71 MB ]