Details:

Alternative Title:
J Cell Biol
Publisher's site:
http://dx.doi.org/10.1083/jcb.201308087
Personal Author:
Brangwynne, Clifford P.
Description:
The coordinated growth of cells and their organelles is a fundamental and poorly understood problem, with implications for processes ranging from embryonic development to oncogenesis. Recent experiments have shed light on the cell size-dependent assembly of membrane-less cytoplasmic and nucleoplasmic structures, including ribonucleoprotein (RNP) granules and other intracellular bodies. Many of these structures behave as condensed liquid-like phases of the cytoplasm/nucleoplasm. The phase transitions that appear to govern their assembly exhibit an intrinsic dependence on cell size, and may explain the size scaling reported for a number of structures. This size scaling could, in turn, play a role in cell growth and size control.
Subject:
[+]
Animals
Cell Enlargement
Cell Size
Centrosome
Gravitation
Intracellular Membranes
Intracellular Space
Organelles
Reviews
Ribonucleoproteins
Spindle Apparatus
Xenopus Laevis

Source:
J Cell Biol. 2013; 203(6):875-881.
Document Type:
Journal Article
Funding:
DP2GM105437-01/DP/NCCDPHP CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:6f49d5515b5ccc540fd7703601a5d841a32a75f6c420b8a28b7b6ad9f95d68af
File Type:

Supporting Files

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