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Phase transitions and size scaling of membrane-less organelles
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Dec 23 2013
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Source: J Cell Biol. 2013; 203(6):875-881.
[PDF-1.71 MB]
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Alternative Title:J Cell Biol
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Description:The coordinated growth of cells and their organelles is a fundamental and poorly understood problem, with implications for processes ranging from embryonic development to oncogenesis. Recent experiments have shed light on the cell size-dependent assembly of membrane-less cytoplasmic and nucleoplasmic structures, including ribonucleoprotein (RNP) granules and other intracellular bodies. Many of these structures behave as condensed liquid-like phases of the cytoplasm/nucleoplasm. The phase transitions that appear to govern their assembly exhibit an intrinsic dependence on cell size, and may explain the size scaling reported for a number of structures. This size scaling could, in turn, play a role in cell growth and size control.
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Volume:203
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Issue:6
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