Antimicrobial Drug Resistance in Escherichia coli from Humans and Food Animals, United States, 1950–2002

Tadesse, Daniel A.; Zhao, Shaohua; Tong, Emily; Ayers, Sherry; Singh, Aparna; Bartholomew, Mary J.; McDermott, Patrick F.

doi:10.3201/eid1805.111153

i

Antimicrobial Drug Resistance in Escherichia coli from Humans and Food Animals, United States, 1950–2002

Supporting Files Public Domain

May 2012
By Tadesse, Daniel A. ; Zhao, Shaohua ; Tong, Emily ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Tadesse, Daniel A. ; Zhao, Shaohua ; Tong, Emily ; Ayers, Sherry ; Singh, Aparna ; Bartholomew, Mary J. ; McDermott, Patrick F. ; Tadesse, Daniel A. ; Zhao, Shaohua ; Tong, Emily ; Ayers, Sherry ; Singh, Aparna ; Bartholomew, Mary J. ; McDermott, Patrick F.
Description:

We conducted a retrospective study of Escherichia coli isolates recovered from human and food animal samples during 1950-2002 to assess historical changes in antimicrobial drug resistance. A total of 1,729 E. coli isolates (983 from humans, 323 from cattle, 138 from chickens, and 285 from pigs) were tested for susceptibility to 15 antimicrobial drugs. A significant upward trend in resistance was observed for ampicillin (p<0.001), sulfonamide (p<0.001), and tetracycline (p<0.001). Animal strains showed increased resistance to 11/15 antimicrobial agents, including ampicillin (p<0.001), sulfonamide (p<0.01), and gentamicin (p<0.001). Multidrug resistance (≥3 antimicrobial drug classes) in E. coli increased from 7.2% during the 1950s to 63.6% during the 2000s. The most frequent co-resistant phenotype observed was to tetracycline and streptomycin (29.7%), followed by tetracycline and sulfonamide (29.0%). These data describe the evolution of resistance after introduction of new antimicrobial agents into clinical medicine and help explain the range of resistance in modern E. coli isolates.
Subjects:

Animals Anti-Bacterial Agents Cattle Cattle Diseases Chickens Drug Resistance, Bacterial Escherichia Coli Infections Humans Microbial Sensitivity Tests Poultry Diseases Retrospective Studies Swine Swine Diseases
Source:

Emerg Infect Dis. 18(5):741-749. ; Emerg Infect Dis. 18(5):741-749.
Document Type:

Journal Article
Place as Subject:

United States
Volume:

18
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:a302fca795c9b4f9b6ec3005743ee8aa67904a5691b9c3246cf6495ef5ee5d62
Download URL:

https://stacks.cdc.gov/view/cdc/23904/cdc_23904_DS1.pdf
File Type:

[PDF - 483.77 KB ]

File Language:

English

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