Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1805.111153
Personal Author:
Tadesse, Daniel A. ; Zhao, Shaohua ; Tong, Emily ; Ayers, Sherry ; Singh, Aparna ; ... More +
Tadesse, Daniel A. ; Zhao, Shaohua ; Tong, Emily ; Ayers, Sherry ; Singh, Aparna ; Bartholomew, Mary J. ; McDermott, Patrick F. Less -
Description:
We conducted a retrospective study of Escherichia coli isolates recovered from human and food animal samples during 1950-2002 to assess historical changes in antimicrobial drug resistance. A total of 1,729 E. coli isolates (983 from humans, 323 from cattle, 138 from chickens, and 285 from pigs) were tested for susceptibility to 15 antimicrobial drugs. A significant upward trend in resistance was observed for ampicillin (p<0.001), sulfonamide (p<0.001), and tetracycline (p<0.001). Animal strains showed increased resistance to 11/15 antimicrobial agents, including ampicillin (p<0.001), sulfonamide (p<0.01), and gentamicin (p<0.001). Multidrug resistance (≥3 antimicrobial drug classes) in E. coli increased from 7.2% during the 1950s to 63.6% during the 2000s. The most frequent co-resistant phenotype observed was to tetracycline and streptomycin (29.7%), followed by tetracycline and sulfonamide (29.0%). These data describe the evolution of resistance after introduction of new antimicrobial agents into clinical medicine and help explain the range of resistance in modern E. coli isolates.
Subject:
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Animals
Anti-Bacterial Agents
Cattle
Cattle Diseases
Chickens
Drug Resistance, Bacterial
Escherichia Coli Infections
Humans
Microbial Sensitivity Tests
Poultry Diseases
Retrospective Studies
Swine
Swine Diseases

Source:
Emerg Infect Dis. 18(5):741-749.
Document Type:
Journal Article
Place as Subject:
United States
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:a302fca795c9b4f9b6ec3005743ee8aa67904a5691b9c3246cf6495ef5ee5d62
File Type:

Supporting Files

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