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Genomic Analysis of emm59 Group A Streptococcus Invasive Strains, United States
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  1. Hypervirulent emm59 Clone in Invasive Group A Streptococcus Outbreak, Southwestern United States
    Personal Author:
    Engelthaler, David M.; Valentine, Michael; Bowers, Jolene; Pistole, Jennifer; Driebe, Elizabeth M.; Terriquez, Joel; Nienstadt, Linus; Carroll, Mark; Schumacher, Mare; Ormsby, Mary Ellen; Brady, Shane; Livar, Eugene; Yazzie, Del; Waddell, Victor; Peoples, Marie; Komatsu, Kenneth; Keim, Paul;
    Published Date:
    Apr 2016
    Source:
    Emerg Infect Dis. 22(4):734-738.
    Description:
    The hyper-virulent emm59 genotype of invasive group A Streptococcus was identified in northern Arizona in 2015. Eighteen isolates belonging to a genomic cluster grouped most closely with recently identified isolates in New Mexico. The continued trans...
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    Filetype[PDF - 552.56 KB]
  2. Spread of Virulent Group A Streptococcus Type emm59 from Montana to Wyoming, USA
    Personal Author:
    Brown, Christopher C.; Olsen, Randall J.; Fittipaldi, Nahuel; Morman, Monica L.; Fort, Peter L.; Neuwirth, Robert; Majeed, Mohammed; Woodward, William B.; Musser, James M.;
    Published Date:
    Apr 2014
    Source:
    Emerg Infect Dis. 20(4):679-681.
    Description:
    Full-genome sequencing showed that a recently emerged and hypervirulent clone of group A | type | active in Canada and parts of the United States has now caused severe invasive infections in rural northeastern Wyoming. Phylogenetic analysis of genome...
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    Filetype[PDF - 286.37 KB]
  3. Disparate Effects of Invasive Group A Streptococcus on Native Americans
    Personal Author:
    Close, Ryan M.; McAuley, James B.;
    Published Date:
    Sep 2020
    Source:
    Emerg Infect Dis. 26(9):1971-1977
    Description:
    Active surveillance of invasive group A Streptococcus (iGAS) disease indicates that its incidence in the US general population is low, but limited studies show rates for American Indians and Alaska Natives (AI/AN) are severalfold higher. Major dispar...
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    Filetype[PDF - 363.77 KB]
  4. Outbreak of invasive infections from subtype emm26.3 group A Streptococcus among homeless adults—Anchorage, Alaska, 2016–2017
    Personal Author:
    Mosites, Emily; Frick, Anna; Gounder, Prabhu; Castrodale, Louisa; Li, Yuan; Rudolph, Karen; Hurlburt, Debby; Lecy, Kristen D.; Zulz, Tammy; Adebanjo, Tolu; Onukwube, Jennifer; Beall, Bernard; Van Beneden, Chris A.; Hennessy, Thomas; McLaughlin, Joseph; Bruce, Michael;
    Published Date:
    Mar 19 2018
    Source:
    Clin Infect Dis. 66(7):1068-1074
    Description:
    BackgroundIn 2016, we detected an outbreak of group A Streptococcus (GAS) invasive infections among the estimated 1000 persons experiencing homelessness (PEH) in Anchorage, Alaska. We characterized the outbreak and implemented a mass antibiotic inter...
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    Filetype[PDF - 548.39 KB]
  5. Genomic Surveillance of Streptococcus pyogenes Strains Causing Invasive Disease, United States, 2016–2017
    Personal Author:
    Li, Yuan; Rivers, Joy; Mathis, Saundra; Li, Zhongya; Velusamy, Srinivasan; Nanduri, Srinivas A.; Van Beneden, Chris A.; Snippes-Vagnone, Paula; Lynfield, Ruth; McGee, Lesley; Chochua, Sopio; Metcalf, Benjamin J.; Beall, Bernard;
    Published Date:
    July 24 2020
    Source:
    Front Microbiol. 2020; 11
    Description:
    BackgroundStreptococcus pyogenes is a major cause of severe, invasive infections in humans. The bacterial pathogen harbors a wide array of virulence factors and exhibits high genomic diversity. Rapid changes of circulating strains in a community are ...
    File Type:
    Filetype[PDF - 1.23 MB]