Shiga Toxin–producing Escherichia coli Serotype O78:H– in Family, Finland, 2009

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lienemann, Taru ; Salo, Eeva ; Rimhanen-Finne, Ruska ; Rönnholm, Kai ; Taimisto, Mari ; Hirvonen, Jari J. ; Tarkka, Eveliina ; Kuusi, Markku ; Siitonen, Anja
• Description:
  Shiga toxin-producing Escherichia coli (STEC) is a pathogen that causes gastroenteritis and bloody diarrhea but can lead to severe disease, such as hemolytic uremic syndrome (HUS). STEC serotype O78:H(-) is rare among humans, and infections are often asymptomatic. We detected a sorbitol-fermenting STEC O78:H(-):stx(1c):hlyA in blood and fecal samples of a 2-week-old boy who had bacteremia and HUS and in fecal samples of his asymptomatic family members. The phenotypic and genotypic characteristics and the virulence properties of this invasive STEC were investigated. Our findings demonstrate that contrary to earlier suggestions, STEC under certain conditions can invade the human bloodstream. Moreover, this study highlights the need to implement appropriate diagnostic methods for identifying the whole spectrum of STEC strains associated with HUS.
• Subjects:
  Anti-Bacterial Agents Bacteremia Bacteria Cluster Analysis Cross-contamination Diarrhea, Infantile Escherichia Coli Infections Feces Hemolytic Uremic Syndrome (HUS) Humans Infant, Newborn Invasive Shiga Toxin–producing E. Coli Male Molecular Typing Phenotype Research Sequence Analysis, DNA Shiga-Toxigenic Escherichia Coli Shiga Toxin 1 STEC Stx1c Virulence Factors Zoonoses

  More +
• Source:
  Emerg Infect Dis. 18(4):577-581.
• Document Type:
  Journal Article
• Volume:
  18
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:31ff80c33c3377ea1089665415ab187110537658c18a5c2ed137b4c3bfccdf3e
• Download URL:
  https://stacks.cdc.gov/view/cdc/23869/cdc_23869_DS1.pdf
• File Type:
  [PDF - 166.64 KB ]