Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

de Steenwinkel, Jurriaan E.M.; ten Kate, Marian T.; de Knegt, Gerjo J.; Kremer, Kristin; Aarnoutse, Rob E.; Boeree, Martin J.; Verbrugh, Henri A.; van Soolingen, Dick; Bakker-Woudenberg, Irma A.J.M.

doi:10.3201/eid1804.110912

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Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

Published Date:

Apr 2012

Publisher's site:

http://dx.doi.org/10.3201/eid1804.110912

Source:

Emerg Infect Dis. 18(4):660-663.

[PDF-378.24 KB]

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Alternative Title:

Emerg Infect Dis

Personal Author:

de Steenwinkel, Jurriaan E.M. ; ten Kate, Marian T. ; de Knegt, Gerjo J. ; Kremer, Kristin ; Aarnoutse, Rob E. ; ... More ▼

Description:

To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high rates of mutation within a wide range of drug concentrations, possibly explaining this genotype's association with multidrug-resistant tuberculosis.

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Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

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