Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  de Steenwinkel, Jurriaan E.M. ; ten Kate, Marian T. ; de Knegt, Gerjo J. ; Kremer, Kristin ; Aarnoutse, Rob E. ; Boeree, Martin J. ; Verbrugh, Henri A. ; van Soolingen, Dick ; Bakker-Woudenberg, Irma A.J.M.
• Description:
  To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high rates of mutation within a wide range of drug concentrations, possibly explaining this genotype's association with multidrug-resistant tuberculosis.
• Subjects:
  Amikacin Antimicrobial Resistances Antitubercular Agents Antituberculosis Drugs Aza Compounds Bacterial Proteins Beijing Genotype Strains Dispatch Drug Resistance, Multiple, Bacterial Emergence Genotype Isoniazid Mdr Tb Microbial Sensitivity Tests Multidrug-Resistant Tuberculosis Mutation Mycobacterium Tuberculosis Quinolines Resistance Rifampin Statistics, Nonparametric Tuberculosis, Multidrug-Resistant Tuberculosis And Other Mycobacteria

  More +
• Source:
  Emerg Infect Dis. 18(4):660-663.
• Document Type:
  Journal Article
• Volume:
  18
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:250a67ff0076fc6d017059c38912f9849e52ae6b3f985725726b05a6112b317a
• Download URL:
  https://stacks.cdc.gov/view/cdc/23860/cdc_23860_DS1.pdf
• File Type:
  [PDF - 378.24 KB ]