Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Ahuka-Mundeke, Steve ; Ayouba, Ahidjo ; Mbala-Kingebeni, Placide ; Liegeois, Florian ; Esteban, Amandine ; ... More +
Ahuka-Mundeke, Steve ; Ayouba, Ahidjo ; Mbala-Kingebeni, Placide ; Liegeois, Florian ; Esteban, Amandine ; Lunguya-Metila, Octavie ; Demba, Didace ; Bilulu, Guy ; Mbenzo-Abokome, Valentin ; Inogwabini, Bila-Isia ; Muyembe-Tamfum, Jean-Jacques ; Delaporte, Eric ; Peeters, Martine Less -
Description:
Like most emerging infectious disease viruses, HIV is also of zoonotic origin. To assess the risk for cross-species transmission of simian immunodeficiency viruses (SIVs) from nonhuman primates to humans in the Democratic Republic of Congo, we collected 330 samples derived from nonhuman primate bushmeat at 3 remote forest sites. SIV prevalences were estimated by using a novel high-throughput assay that included 34 HIV and SIV antigens in a single well. Overall, 19% of nonhuman primate bushmeat was infected with SIVs, and new SIV lineages were identified. Highest SIV prevalences were seen in red-tailed guenons (25%) and Tshuapa red colobus monkeys (24%), representing the most common hunted primate species, thus increasing the likelihood for cross-species transmission. Additional studies are needed to determine whether other SIVs crossed the species barrier. With the newly developed assay, large-scale screening against many antigens is now easier and faster.
Subject:
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Amino Acid Sequence
Animals
Antibodies, Viral
Base Sequence
Colobus
Communicable Diseases, Emerging
Cross Reactions
DNA, Z-Form
Genetic Variation
High-Throughput Screening Assays
HIV-1
HIV Antibodies
HIV Antigens
HIV Infections
Humans
Immunoassay
Molecular Sequence Data
Phylogeny
Primates
Retroviridae Proteins
Seroepidemiologic Studies
Simian Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
Species Specificity
Zoonoses

Source:
Emerg Infect Dis. 17(12):2277-2286.
Document Type:
Journal Article
Funding:
R01 AI 50529/AI/NIAID NIH HHS/United States
Place as Subject:
Democratic Republic of the Congo
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:d55ae5e3d30bf28ab902b3882f6f35ee7f70d246d6eb03ee427b4a5b79fa11ef
File Type:

Supporting Files

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  	license.txt	txt

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