Lineage and Virulence of Streptococcus suis Serotype 2 Isolates from North America

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Fittipaldi, Nahuel ; Xu, Jiangu ; Lacouture, Sonia ; Tharavichitkul, Prasit ; Osaki, Makoto ; Sekizaki, Tsutomu ; Takamatsu, Daisuke ; Gottschalk, Marcelo
• Description:
  We performed multilocus sequence typing of 64 North American Streptococcus suis serotype 2 porcine isolates. Strains were sequence type (ST) 28 (51%), ST25 (44%), and ST1 (5%). We identified nonrandom associations between STs and expression of the virulence markers suilysin (SLY), muramidase-relased protein (MRP), and extracellular factor (EF). Expression of pili encoded by the srtF and srtG pilus clusters was also nonrandomly associated with STs. ST1 strains were SLY+ EF+ MRP+ srtF pilus+ srtG pilus-. ST25 strains were SLY- EF- MRP- srtF pilus- srtG pilus+, and most ST28 strains were SLY- MRP+ EF- srtF pilus+ srtG pilus+. ST28 isolates proved essentially nonvirulent in a mouse infection model; ST25 strains showed moderate virulence and ST1 isolates were highly virulent. ST1 is responsible for a high proportion of S. suis disease in humans worldwide. Its presence in North America indicates that potential zoonotic S. suis outbreaks in this continent cannot be disregarded.
• Subjects:
  Animals Communicable Diseases, Emerging Female Fimbriae, Bacterial Genes, Bacterial Genotype Humans Multilocus Sequence Typing Serotyping Streptococcal Infections Sus Scrofa Swine Swine Diseases Virulence Zoonoses

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• Source:
  Emerg Infect Dis. 17(12):2239-2244.
• Document Type:
  Journal Article
• Funding:
  Canadian Institutes of Health Research/Canada
• Volume:
  17
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8836675478a8503a87541201c7c2b7706cc22bcf59a26f41c85e7cc3b120a7fa
• Download URL:
  https://stacks.cdc.gov/view/cdc/23780/cdc_23780_DS1.pdf
• File Type:
  [PDF - 233.63 KB ]