Considerations for Oral Cholera Vaccine Use during Outbreak after Earthquake in Haiti, 2010−2011

Date, Kashmira A.; Vicari, Andrea; Hyde, Terri B.; Mintz, Eric; Danovaro-Holliday, M. Carolina; Henry, Ariel; Tappero, Jordan W.; Roels, Thierry H.; Abrams, Joseph; Burkholder, Brenton T.; Ruiz-Matus, Cuauhtémoc; Andrus, Jon; Dietz, Vance

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Considerations for Oral Cholera Vaccine Use during Outbreak after Earthquake in Haiti, 2010−2011

Supporting Files Public Domain

Nov 2011
By Date, Kashmira A. ; Vicari, Andrea ; Hyde, Terri B. ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Date, Kashmira A. ; Vicari, Andrea ; Hyde, Terri B. ; Mintz, Eric ; Danovaro-Holliday, M. Carolina ; Henry, Ariel ; Tappero, Jordan W. ; Roels, Thierry H. ; Abrams, Joseph ; Burkholder, Brenton T. ; Ruiz-Matus, Cuauhtémoc ; Andrus, Jon ; Dietz, Vance
Description:

Oral cholera vaccines (OCVs) have been recommended in cholera-endemic settings and preemptively during outbreaks and complex emergencies. However, experience and guidelines for reactive use after an outbreak has started are limited. In 2010, after over a century without epidemic cholera, an outbreak was reported in Haiti after an earthquake. As intensive nonvaccine cholera control measures were initiated, the feasibility of OCV use was considered. We reviewed OCV characteristics and recommendations for their use and assessed global vaccine availability and capacity to implement a vaccination campaign. Real-time modeling was conducted to estimate vaccine impact. Ultimately, cholera vaccination was not implemented because of limited vaccine availability, complex logistical and operational challenges of a multidose regimen, and obstacles to conducting a campaign in a setting with population displacement and civil unrest. Use of OCVs is an option for cholera control; guidelines for their appropriate use in epidemic and emergency settings are urgently needed.
Subjects:

Administration, Oral Bacteria Cholera Cholera Vaccines Disease Outbreaks Earthquakes Emergencies Enteric Infections Humans Mass Vaccination OCV Oral Cholera Vaccine Synopsis Vaccines Waterborne Infections
Source:

Emerg Infect Dis. 17(11):2105-2112.
Document Type:

Journal Article
Place as Subject:

Haiti
Location:

Caribbean
Volume:

17
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:deb2bf85f193a0e2c3c292d700c913ddfc614cccbf7531712060b09156f7e9f4
Download URL:

https://stacks.cdc.gov/view/cdc/23744/cdc_23744_DS1.pdf
File Type:

[PDF - 335.75 KB ]

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