Comparative Genomics of Vibrio cholerae from Haiti, Asia, and Africa

Reimer, Aleisha R.; Van Domselaar, Gary; Stroika, Steven; Walker, Matthew; Kent, Heather; Tarr, Cheryl; Talkington, Deborah; Rowe, Lori; Olsen-Rasmussen, Melissa; Frace, Michael; Sammons, Scott; Dahourou, Georges Anicet; Boncy, Jacques; Smith, Anthony M.; Mabon, Philip; Petkau, Aaron; Graham, Morag; Gilmour, Matthew W.; Gerner-Smidt, Peter

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Comparative Genomics of Vibrio cholerae from Haiti, Asia, and Africa

Supporting Files Public Domain

Nov 2011
By Reimer, Aleisha R. ; Van Domselaar, Gary ; Stroika, Steven ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Reimer, Aleisha R. ; Van Domselaar, Gary ; Stroika, Steven ; Walker, Matthew ; Kent, Heather ; Tarr, Cheryl ; Talkington, Deborah ; Rowe, Lori ; Olsen-Rasmussen, Melissa ; Frace, Michael ; Sammons, Scott ; Dahourou, Georges Anicet ; Boncy, Jacques ; Smith, Anthony M. ; Mabon, Philip ; Petkau, Aaron ; Graham, Morag ; Gilmour, Matthew W. ; Gerner-Smidt, Peter
Corporate Authors:

V. cholerae Outbreak Genomics Task Force
Description:

Cholera was absent from the island of Hispaniola at least a century before an outbreak that began in Haiti in the fall of 2010. Pulsed-field gel electrophoresis (PFGE) analysis of clinical isolates from the Haiti outbreak and recent global travelers returning to the United States showed indistinguishable PFGE fingerprints. To better explore the genetic ancestry of the Haiti outbreak strain, we acquired 23 whole-genome Vibrio cholerae sequences: 9 isolates obtained in Haiti or the Dominican Republic, 12 PFGE pattern-matched isolates linked to Asia or Africa, and 2 nonmatched outliers from the Western Hemisphere. Phylogenies for whole-genome sequences and core genome single-nucleotide polymorphisms showed that the Haiti outbreak strain is genetically related to strains originating in India and Cameroon. However, because no identical genetic match was found among sequenced contemporary isolates, a definitive genetic origin for the outbreak in Haiti remains speculative.
Subjects:

Alleles Bacteria Bacterial Proteins Cholera Cholera Toxin Disease Outbreaks Electrophoresis, Gel, Pulsed-Field Epidemiology Gene Order Genome, Bacterial Genomics Humans Interspersed Repetitive Sequences Outbreak Phylogeny Prophages Public Health Research Sequence Homology, Amino Acid Travel Vibrio Cholerae Whole-genome Sequencing
Source:

Emerg Infect Dis. 17(11):2113-2121.
Document Type:

Journal Article
Place as Subject:

Haiti ; Asia ; Africa
Location:

Caribbean ; Asia ; Africa
Volume:

17
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:96a35ea2509fd5c642b2dc8912b5a151a6f469f234383df2dbd44d29af0e6076
Download URL:

https://stacks.cdc.gov/view/cdc/23736/cdc_23736_DS1.pdf
File Type:

[PDF - 359.64 KB ]

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