Mycobacterium chelonae-abscessus Complex Associated with Sinopulmonary Disease, Northeastern USA

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Simmon, Keith E. ; Brown-Elliott, Barbara A. ; Ridge, Perry G. ; Durtschi, Jacob D. ; Mann, Linda Bridge ; Slechta, E. Susan ; Steigerwalt, Arnold G. ; Moser, Benjamin D. ; Whitney, Anne M. ; Brown, June M. ; Voelkerding, Karl V. ; McGowan, Karin L. ; Reilly, Anne F. ; Kirn, Thomas J. ; Butler, W. Ray ; Edelstein, Paul H. ; Wallace, Richard J. ; Petti, Cathy A.
• Description:
  Members of the Mycobacterium chelonae-abscessus complex represent Mycobacterium species that cause invasive infections in immunocompetent and immunocompromised hosts. We report the detection of a new pathogen that had been misidentified as M. chelonae with an atypical antimicrobial drug susceptibility profile. The discovery prompted a multicenter investigation of 26 patients. Almost all patients were from the northeastern United States, and most had underlying sinus or pulmonary disease. Infected patients had clinical features similar to those with M. abscessus infections. Taxonomically, the new pathogen shared molecular identity with members of the M. chelonae-abscessus complex. Multilocus DNA target sequencing, DNA-DNA hybridization, and deep multilocus sequencing (43 full-length genes) support a new taxon for these microorganisms. Because most isolates originated in Pennsylvania, we propose the name M. franklinii sp. nov. This investigation underscores the need for accurate identification of Mycobacterium spp. to detect new pathogens implicated in human disease.
• Subjects:
  Adult Aged Anti-Bacterial Agents Bacterial Proteins Chaperonin 60 CME DNA, Ribosomal Spacer Female High-Throughput Nucleotide Sequencing Humans Male Microbial Sensitivity Tests Middle Aged Multilocus Sequence Typing Mycobacterium Chelonae Mycobacterium Infections, Nontuberculous Nontuberculous Mycobacteria Phylogeny Research Respiratory Tract Infections RNA, Ribosomal, 16S Sinusitis Superoxide Dismutase

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• Source:
  Emerg Infect Dis. 17(9):1692-1700.
• Document Type:
  Journal Article
• Place as Subject:
  Pennsylvania
• Location:
  North America
• Volume:
  17
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:893eb13607979fa4699632ed3b9fe7812099722baa82e3f774aaed6093c7e745
• Download URL:
  https://stacks.cdc.gov/view/cdc/23671/cdc_23671_DS1.pdf
• File Type:
  [PDF - 312.12 KB ]