Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1801.111079
Personal Author:
Hurt, Aeron C. ; Leang, Sook Kwan ; Speers, David J. ; Barr, Ian G. ; Maurer-Stroh, Sebastian
Hurt, Aeron C. ; Leang, Sook Kwan ; Speers, David J. ; Barr, Ian G. ; Maurer-Stroh, Sebastian Less -
Description:
Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity.
Subjects:
[+]
Antiviral Agents Dispatch Drug Resistance, Viral Global Health Humans Influenza, Human Influenza A Virus, H1N1 Subtype Models, Molecular Oseltamivir Pandemics Protein Conformation
Source:
Emerg Infect Dis. 18(1):109-112.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:27d5c0a636f62c5825119c0b904ba62a9de7a7990150daaf3fe86767b76912d3
Download URL:
https://stacks.cdc.gov/view/cdc/23644/cdc_23644_DS1.pdf
File Type:

Supporting Files

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  	11-1079-F2.jpg	jpeg
  	11-1079_finalDexp.nxml	txt
  	license.txt	txt

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