Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses

Hurt, Aeron C.; Leang, Sook Kwan; Speers, David J.; Barr, Ian G.; Maurer-Stroh, Sebastian

doi:10.3201/eid1801.111079

i

Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses

Supporting Files Public Domain

Jan 2012
By Hurt, Aeron C. ; Leang, Sook Kwan ; Speers, David J. ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Hurt, Aeron C. ; Leang, Sook Kwan ; Speers, David J. ; Barr, Ian G. ; Maurer-Stroh, Sebastian
Description:

Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity.
Subjects:

Antiviral Agents Dispatch Drug Resistance, Viral Global Health Humans Influenza, Human Influenza A Virus, H1N1 Subtype Models, Molecular Oseltamivir Pandemics Protein Conformation
Source:

Emerg Infect Dis. 18(1):109-112.
Document Type:

Journal Article
Volume:

18
Issue:

1
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:27d5c0a636f62c5825119c0b904ba62a9de7a7990150daaf3fe86767b76912d3
Download URL:

https://stacks.cdc.gov/view/cdc/23644/cdc_23644_DS1.pdf
File Type:

[PDF - 313.28 KB ]

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.