Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses

Hurt, Aeron C.; Leang, Sook Kwan; Speers, David J.; Barr, Ian G.; Maurer-Stroh, Sebastian

doi:10.3201/eid1801.111079

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Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses

Jan 2012
By Hurt, Aeron C. ; Leang, Sook Kwan ; Speers, David J. ; ...
http://dx.doi.org/10.3201/eid1801.111079
Source: Emerg Infect Dis. 18(1):109-112.

[PDF-313.28 KB]

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Hurt, Aeron C. ; Leang, Sook Kwan ; Speers, David J. ; Barr, Ian G. ; Maurer-Stroh, Sebastian

Hurt, Aeron C. ; Leang, Sook Kwan ; Speers, David J. ; Barr, Ian G. ; Maurer-Stroh, Sebastian Less -
Description:

Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity.
Subjects:

[+]

Antiviral Agents Dispatch Drug Resistance, Viral Global Health Humans Influenza, Human Influenza A Virus, H1N1 Subtype Models, Molecular Oseltamivir Pandemics Protein Conformation
Source:

Emerg Infect Dis. 18(1):109-112.
Document Type:

Journal Article
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

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urn:sha256:27d5c0a636f62c5825119c0b904ba62a9de7a7990150daaf3fe86767b76912d3
Download URL:

https://stacks.cdc.gov/view/cdc/23644/cdc_23644_DS1.pdf
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