Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses
Published Date:Jan 2012
Source:Emerg Infect Dis. 18(1):109-112.
Drug Resistance, Viral
Influenza A Virus, H1N1 Subtype
Description:Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity.
image/gif image/jpeg image/gif image/jpeg text/plain text/plain
You May Also Like: