Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ladhani, Shamez N. ; Lucidarme, Jay ; Newbold, Lynne S. ; Gray, Stephen J. ; Carr, Anthony D. ; Findlow, Jamie ; Ramsay, Mary E. ; Kaczmarski, Edward B. ; Borrow, Raymond
• Description:
  Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39% of patients had underlying medical conditions, and 19% died. MenY isolates causing invasive disease during 2007-2009 belonged mainly to 1 of 4 clonal complexes (cc), cc23 (56% of isolates), cc174 (21%), cc167 (11%), and cc22 (8%). The 2009 increase resulted primarily from sequence type 1655 (cc23) (22 cases in 2009, compared with 4 cases each in 2007 and 2008). cc23 was associated with lpxL1 mutations and meningitis in younger age groups (<25 years); cc174 was associated with nonmeningitis, particularly pneumonia, in older age groups (>65 years). The increase in MenY disease requires careful epidemiologic and molecular monitoring.
• Subjects:
  Acyltransferases Adolescent Adult Aged Aged, 80 And Over Age Distribution Bacteria Bacterial Proteins Capsular Group Y Child Child, Preschool England Gene Expression Regulation, Bacterial Humans Infant Infant, Newborn LpxL1 Meningococcal Meningococcal Infections Middle Aged Mutation NadA Neisseria Meningitidis, Serogroup Y Outcome Population Surveillance Research Time Factors Vaccine Wales Young Adult

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• Source:
  Emerg Infect Dis. 18(1):63-70.
• Document Type:
  Journal Article
• Volume:
  18
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6aeed4d8fdf8b28ed7a5725115c3a4df22037e4ebf7ef87df1e03d17b335adb3
• Download URL:
  https://stacks.cdc.gov/view/cdc/23636/cdc_23636_DS1.pdf
• File Type:
  [PDF - 322.11 KB ]