Intestinal Toxemia Botulism in 3 Adults, Ontario, Canada, 2006–2008

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Sheppard, Yolanda D. ; Middleton, Dean ; Whitfield, Yvonne ; Tyndel, Felix ; Haider, Shariq ; Spiegelman, Jamie ; Swartz, Richard H. ; Nelder, Mark P. ; Baker, Stacey L. ; Landry, Lisa ; MacEachern, Ross ; Deamond, Sherri ; Ross, Lorrie ; Peters, Garth ; Baird, Michelle ; Rose, David ; Sanders, Greg ; Austin, John W.
• Description:
  Five cases of intestinal toxemia botulism in adults were identified within an 18-month period in or near Toronto, Ontario, Canada. We describe findings for 3 of the 5 case-patients. Clinical samples contained Clostridium botulinum spores and botulinum neurotoxins (types A and B) for extended periods (range 41-61 days), indicative of intestinal toxemia botulism. Patients' clinical signs improved with supportive care and administration of botulinum antitoxin. Peanut butter from the residence of 1 case-patient yielded C. botulinum type A, which corresponded with type A spores found in the patient's feces. The food and clinical isolates from this case-patient could not be distinguished by pulsed-field gel electrophoresis. Two of the case-patients had Crohn disease and had undergone previous bowel surgery, which may have contributed to infection with C. botulinum. These cases reinforce the view that an underlying gastrointestinal condition is a risk factor for adult intestinal toxemia botulism.
• Subjects:
  Botulinum Antitoxin Botulism Feces Female Humans Male Middle Aged
• Source:
  Emerg Infect Dis. 18(1):1-6.
• Document Type:
  Journal Article
• Place as Subject:
  Ontario, Canada
• Location:
  North America
• Volume:
  18
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:2a676068dc8247691303ca47345de1583d183595c660f3ac82b427619dd2edd4
• Download URL:
  https://stacks.cdc.gov/view/cdc/23623/cdc_23623_DS1.pdf
• File Type:
  [PDF - 208.05 KB ]