Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1801.110336
Personal Author:
Jackson, Michael L.; Rose, Charles E.; Cohn, Amanda; Coronado, Fatima; Clark, Thomas A.; ... More +
Jackson, Michael L.; Rose, Charles E.; Cohn, Amanda; Coronado, Fatima; Clark, Thomas A.; Wenger, Jay D.; Bulkow, Lisa; Bruce, Michael G.; Messonnier, Nancy E.; Hennessy, Thomas W.; Less -
Description:
In response to the 2007-2009 Haemophilus influenzae type b (Hib) vaccine shortage in the United States, we developed a flexible model of Hib transmission and disease for optimizing Hib vaccine programs in diverse populations and situations. The model classifies population members by age, colonization/disease status, and antibody levels, with movement across categories defined by differential equations. We implemented the model for the United States as a whole, England and Wales, and the Alaska Native population. This model accurately simulated Hib incidence in all 3 populations, including the increased incidence in England/Wales beginning in 1999 and the change in Hib incidence in Alaska Natives after switching Hib vaccines in 1996. The model suggests that a vaccine shortage requiring deferral of the booster dose could last 3 years in the United States before loss of herd immunity would result in increasing rates of invasive Hib disease in children <5 years of age.
Subject:
[+]
Alaskan Natives
Child
Child, Preschool
Haemophilus Infections
Haemophilus Vaccines
Humans
Immunity, Herd
Incidence
Indians, North American
Infant
Models, Biological
Time Factors

Source:
Emerg Infect Dis. 18(1):13-20.;
Document Type:
Journal Article;
Place as Subject:
United States; England; Wales; Alaska;
United States; England; Wales; Alaska; Less -
Collection(s):
Arctic Investigations Program
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:0703c7dc0d9148988fbe422842ac08c70ae21fdbf67fdfae636065347f2d184e
File Type:

Supporting Files

• 	11-0336-Techapp1_2p.pdf	pdf
  	11-0336-Techapp2_8p.pdf	pdf
  	11-0336-Techapp3_6p.pdf	pdf
  	11-0336_finalR.nxml	txt
  	license.txt	txt
  	11-0336-F1.gif	gif
  	11-0336-F1.jpg	jpeg
  	11-0336-F2.gif	gif
  	11-0336-F2.jpg	jpeg
  	11-0336-F3.gif	gif
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  	11-0336-F4.jpg	jpeg

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