Modeling Insights into Haemophilus influenzae Type b Disease, Transmission, and Vaccine Programs

Jackson, Michael L.; Rose, Charles E.; Cohn, Amanda; Coronado, Fatima; Clark, Thomas A.; Wenger, Jay D.; Bulkow, Lisa; Bruce, Michael G.; Messonnier, Nancy E.; Hennessy, Thomas W.

doi:10.3201/eid1801.110336

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Modeling Insights into Haemophilus influenzae Type b Disease, Transmission, and Vaccine Programs

Published Date:

Jan 2012

Publisher's site:

http://dx.doi.org/10.3201/eid1801.110336 New Site Icon

Source:

Emerg Infect Dis. 18(1):13-20.

[PDF - 443.75 KB]

Details:

Personal Authors:

Jackson, Michael L. ; Rose, Charles E. ; Cohn, Amanda ; Coronado, Fatima ; Clark, Thomas A. ; ... More ▼

Keywords:

[+]

Description:

In response to the 2007-2009 Haemophilus influenzae type b (Hib) vaccine shortage in the United States, we developed a flexible model of Hib transmission and disease for optimizing Hib vaccine programs in diverse populations and situations. The model classifies population members by age, colonization/disease status, and antibody levels, with movement across categories defined by differential equations. We implemented the model for the United States as a whole, England and Wales, and the Alaska Native population. This model accurately simulated Hib incidence in all 3 populations, including the increased incidence in England/Wales beginning in 1999 and the change in Hib incidence in Alaska Natives after switching Hib vaccines in 1996. The model suggests that a vaccine shortage requiring deferral of the booster dose could last 3 years in the United States before loss of herd immunity would result in increasing rates of invasive Hib disease in children <5 years of age.

Document Type:

Journal Article

Collection(s):

Arctic Investigations Program
Emerging Infectious Diseases

Supporting Files:

11-0336-F1.gif	image/gif
11-0336-F1.jpg	image/jpeg
11-0336-F2.gif	image/gif
11-0336-F2.jpg	image/jpeg
11-0336-F3.gif	image/gif
11-0336-F3.jpg	image/jpeg
11-0336-F4.gif	image/gif
11-0336-F4.jpg	image/jpeg
11-0336-Techapp1_2p.pdf	application/pdf
11-0336-Techapp2_8p.pdf	application/pdf
11-0336-Techapp3_6p.pdf	application/pdf
11-0336_finalR.nxml	text/plain
license.txt	text/plain

No Related Documents.

You May Also Like:

Haemophilus influenzae Type b Disease and Vaccine Booster Dose Deferral, United States, 1998–2009

Personal Author:

Briere, Elizabeth C.; Jackson, Michael; Shah, Shetul G.; Cohn, Amanda C.; Anderson, Raydel D.; MacNeil, Jessica R.; Coronado, Fatima M.; Mayer, Leonard W.; Clark, Thomas A.; Messonnier, Nancy E.;

Published:

Aug 06 2012

Source:

Pediatrics. 130(3):414-420.

Description:

BACKGROUND : Since the introduction of effective vaccines, the incidence of invasive Haemophilus influenzae type b (Hib) disease among children <5 years of age has decreased by 99% in the United States. In response to a limited vaccine supply that...

File Type:

[PDF - 319.97 KB]
Bacterial Meningitis and Haemophilus influenzae Type b Conjugate Vaccine, Malawi

Personal Author:

McCormick, David W.; Molyneux, Elizabeth M.;

Published:

Apr 2011

Source:

Emerg Infect Dis. 17(4):688-690.

Description:

A retrospective database review showed that Haemophilus influenzae type b conjugate vaccine decreased the annual number of cases of H. influenzae type b meningitis in children in Blantyre, Malawi. Among young bacterial meningitis patients, HIV preval...

File Type:

[PDF - 198.75 KB]
Impact of Introduction of the Haemophilus influenzae Type b Conjugate Vaccine into Childhood Immunization on Meningitis in Bangladeshi Infants

Personal Author:

Sultana, Nadira K.; Saha, Samir K.; Al-Emran, Hassan M.; Modak, Joyanta K.; Sharker, M. A. Yushuf; El-Arifeen, Shams; Cohen, Adam L.; Baqui, Abdullah H.; Luby, Stephen P.;

Published:

Jul 2013

Source:

J Pediatr. 163(1 0):S73-S78.

Description:

Objectives : Some Asian countries have been reluctant to adopt Haemophilus influenzae type b (Hib) conjugate vaccination because of uncertainty over disease burden. We assessed the impact of introduction of Hib conjugate vaccine into the Expanded Pro...

File Type:

[PDF - 128.69 KB]
Rapid Assessment Tool for Haemophilus influenzae type b Disease in Developing Countries1

Personal Author:

Feikin, Daniel R.; Nelson, Christopher B.; Watt, James P.; Mohsni, Ezzeddine; Wenger, Jay D.; Levine, Orin S.;

Published:

Jul 2004

Source:

Emerg Infect Dis. 10(7):1270-1276.

Description:

Haemophilus influenzae type b (Hib) still causes a substantial number of deaths among children in developing countries, despite the availability of effective conjugate vaccines. A major obstacle in developing a Hib vaccine has been limited awareness ...

File Type:

[PDF - 164.21 KB]
Haemophilus influenzae Type b Invasive Disease in Amish Children, Missouri, USA, 2014

Personal Author:

Myers, Angela L.; Jackson, Mary Anne; Zhang, Lixin; Swanson, Douglas S.; Gilsdorf, Janet R.;

Published:

Jan 2017

Source:

Emerg Infect Dis. 23(1):112-114.

Description:

During 5 months in 2014, three Amish children in Missouri, USA, were diagnosed with invasive Haemophilus influenzae type b infection. Two were rural neighbors infected with a genetically similar rare strain, sequence type 45. One child had recently t...

File Type:

[PDF - 808.77 KB]