Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dxdoiorg/103201/eid1801110336
Personal Author:
Jackson, Michael L ; Rose, Charles E ; Cohn, Amanda ; Coronado, Fatima ; Clark, Thomas A ; ... More +
Jackson, Michael L ; Rose, Charles E ; Cohn, Amanda ; Coronado, Fatima ; Clark, Thomas A ; Wenger, Jay D ; Bulkow, Lisa ; Bruce, Michael G ; Messonnier, Nancy E ; Hennessy, Thomas W Less -
Description:
In response to the 2007-2009 Haemophilus influenzae type b (Hib) vaccine shortage in the United States, we developed a flexible model of Hib transmission and disease for optimizing Hib vaccine programs in diverse populations and situations The model classifies population members by age, colonization/disease status, and antibody levels, with movement across categories defined by differential equations We implemented the model for the United States as a whole, England and Wales, and the Alaska Native population This model accurately simulated Hib incidence in all 3 populations, including the increased incidence in England/Wales beginning in 1999 and the change in Hib incidence in Alaska Natives after switching Hib vaccines in 1996 The model suggests that a vaccine shortage requiring deferral of the booster dose could last 3 years in the United States before loss of herd immunity would result in increasing rates of invasive Hib disease in children <5 years of age
Subjects:
[+]
Alaska Natives Child Child, Preschool Haemophilus Infections Haemophilus Vaccines Humans Immunity, Herd Incidence Indians, North American Infant Models, Biological Time Factors
Source:
Emerg Infect Dis 18(1):13-20
Document Type:
Journal Article
Place as Subject:
United States ; England ; Wales ; Alaska
United States ; England ; Wales ; Alaska Less -
Location:
United States ; England ; Wales ; Alaska
United States ; England ; Wales ; Alaska Less -
Collection(s):
CDC Public Access Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:0703c7dc0d9148988fbe422842ac08c70ae21fdbf67fdfae636065347f2d184e
Download URL:
https://stacks.cdc.gov/view/cdc/23618/cdc_23618_DS1.pdf
File Type:

Supporting Files

• 	11-0336-Techapp1_2p.pdf	pdf
  	11-0336-Techapp2_8p.pdf	pdf
  	11-0336-Techapp3_6p.pdf	pdf
  	11-0336_finalR.nxml	txt
  	license.txt	txt
  	11-0336-F1.gif	gif
  	11-0336-F1.jpg	jpeg
  	11-0336-F2.gif	gif
  	11-0336-F2.jpg	jpeg
  	11-0336-F3.gif	gif
  	11-0336-F3.jpg	jpeg
  	11-0336-F4.gif	gif
  	11-0336-F4.jpg	jpeg

More +