Iatrogenic Creutzfeldt-Jakob Disease, Final Assessment

Brown, Paul; Brandel, Jean-Philippe; Sato, Takeshi; Nakamura, Yosikazu; MacKenzie, Jan; Will, Robert G.; Ladogana, Anna; Pocchiari, Maurizio; Leschek, Ellen W.; Schonberger, Lawrence B.

doi:10.3201/eid1806.120116

i

Iatrogenic Creutzfeldt-Jakob Disease, Final Assessment

Supporting Files Public Domain

Jun 2012
By Brown, Paul ; Brandel, Jean-Philippe ; Sato, Takeshi ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Brown, Paul ; Brandel, Jean-Philippe ; Sato, Takeshi ; Nakamura, Yosikazu ; MacKenzie, Jan ; Will, Robert G. ; Ladogana, Anna ; Pocchiari, Maurizio ; Leschek, Ellen W. ; Schonberger, Lawrence B. ; Brown, Paul ; Brandel, Jean-Philippe ; Sato, Takeshi ; Nakamura, Yosikazu ; MacKenzie, Jan ; Will, Robert G. ; Ladogana, Anna ; Pocchiari, Maurizio ; Leschek, Ellen W. ; Schonberger, Lawrence B.
Description:

The era of iatrogenic Creutzfeldt-Jakob disease (CJD) has nearly closed; only occasional cases with exceptionally long incubation periods are still appearing. The principal sources of these outbreaks are contaminated growth hormone (226 cases) and dura mater grafts (228 cases) derived from human cadavers with undiagnosed CJD infections; a small number of additional cases are caused by neurosurgical instrument contamination, corneal grafts, gonadotrophic hormone, and secondary infection with variant CJD transmitted by transfusion of blood products. No new sources of disease have been identified, and current practices, which combine improved recognition of potentially infected persons with new disinfection methods for fragile surgical instruments and biological products, should continue to minimize the risk for iatrogenic disease until a blood screening test for the detection of preclinical infection is validated for human use.
Subjects:

CME Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome Drug Contamination Dura Mater Equipment Contamination Human Growth Hormone Humans Iatrogenic Disease Incidence Prions And Related Diseases PRNP Codon 129 Synopsis Transplants Variant Creutzfeldt-Jakob Disease
Source:

Emerg Infect Dis. 18(6):901-907. ; Emerg Infect Dis. 18(6):901-907.
Document Type:

Journal Article
Volume:

18
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:548196a6532e08d1a62595e90976d6e5e088fa3c8de4554b1c279d72dafb1930
Download URL:

https://stacks.cdc.gov/view/cdc/23596/cdc_23596_DS1.pdf
File Type:

[PDF - 291.48 KB ]

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