Macrolide-Resistant Bordetella pertussis Infection in Newborn Girl, France
Published Date:Jun 2012
Source:Emerg Infect Dis. 18(6):966-968.
DNA Mutational Analysis
Drug Resistance, Bacterial
Exchange Transfusion, Whole Blood
RNA, Ribosomal, 23S
Description:A macrolide antimicrobial drug was administered to a newborn with cough. On day 23 of hospitalization, macrolide-resistant Bordetella pertussis was isolated from nasopharyngeal aspirates. DNA sequencing and PCR-restriction fragment length polymorphism showed a 2047 A-to-G mutation in the 3 copies of the 23S rRNA gene. Monitoring for macrolide resistance is essential in infants <6 months of age.
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