Molecular Epidemiology of Geographically Dispersed Vibrio cholerae, Kenya, January 2009–May 2010

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Mohamed, Ahmed Abade ; Oundo, Joseph ; Kariuki, Samuel M. ; Boga, Hamadi I. ; Sharif, Shanaz K. ; Akhwale, Willis ; Omolo, Jared ; Amwayi, Anyangu S. ; Mutonga, David ; Kareko, David ; Njeru, Mercy ; Li, Shan ; Breiman, Robert F. ; Stine, O. Colin
• Description:
  Numerous outbreaks of cholera have occurred in Kenya since 1971. To more fully understand the epidemiology of cholera in Kenya, we analyzed the genetic relationships among 170 Vibrio cholerae O1 isolates at 5 loci containing variable tandem repeats. The isolates were collected during January 2009-May 2010 from various geographic areas throughout the country. The isolates grouped genetically into 5 clonal complexes, each comprising a series of genotypes that differed by an allelic change at a single locus. No obvious correlation between the geographic locations of the isolates and their genotypes was observed. Nevertheless, geographic differentiation of the clonal complexes occurred. Our analyses showed that multiple genetic lineages of V. cholerae were simultaneously infecting persons in Kenya. This finding is consistent with the simultaneous emergence of multiple distinct genetic lineages of V. cholerae from endemic environmental reservoirs rather than recent introduction and spread by travelers.
• Subjects:
  Adolescent Adult Aged Child Child, Preschool Cholera Disease Outbreaks Genes, Bacterial Genotype Humans Infant Middle Aged Minisatellite Repeats Multilocus Sequence Typing Phylogeny Phylogeography Research Young Adult

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• Source:
  Emerg Infect Dis. 18(6):925-931.
• Document Type:
  Journal Article
• Funding:
  N01-AI-40014325/AI/NIAID NIH HHS/United States ; R0-1A1039129/PHS HHS/United States
• Place as Subject:
  Kenya
• Location:
  Africa
• Volume:
  18
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e234d2537428a8241abc5eff3f83a12b65772cc134a40af997f895e4db86d5b3
• Download URL:
  https://stacks.cdc.gov/view/cdc/23590/cdc_23590_DS1.pdf
• File Type:
  [PDF - 329.45 KB ]