Corrigendum: Persisting Cryptococcus Yeast Species Vishniacozyma Victoriae and Cryptococcus Neoformans Elicit Unique Airway Inflammation in Mice Following Repeated Exposure

Details

• Personal Author:
  Blackwood, Catherine B. ; Croston, Tara L. ; Dannemiller, Karen C. ; Green, Brett J. ; Lemons, Angela R. ; Rush, Rachael E.
• Description:
  Background: Allergic airway disease (AAD) is a growing concern in industrialized nations and can be influenced by fungal exposures. Basidiomycota yeast species such as Cryptococcus neoformans are known to exacerbate allergic airway disease; however, recent indoor assessments have identified other Basidiomycota yeasts, including Vishniacozyma victoriae (syn. Cryptococcus victoriae), to be prevalent and potentially associated with asthma. Until now, the murine pulmonary immune response to repeated V. victoriae exposure was previously unexplored. Objective: This study aimed to compare the immunological impact of repeated pulmonary exposure to Cryptococcus yeasts. Methods: Mice were repeatedly exposed to an immunogenic dose of C. neoformans or V. victoriae via oropharyngeal aspiration. Bronchoalveolar lavage fluid (BALF) and lungs were collected to examine airway remodeling, inflammation, mucous production, cellular influx, and cytokine responses at 1 day and 21 days post final exposure. The responses to C. neoformans and V. victoriae were analyzed and compared. Results: Following repeated exposure, both C. neoformans and V. victoriae cells were still detectable in the lungs 21 days post final exposure. Repeated C. neoformans exposure initiated myeloid and lymphoid cellular infiltration into the lung that worsened over time, as well as an IL-4 and IL-5 response compared to PBS-exposed controls. In contrast, repeated V. victoriae exposure induced a strong CD4+ T cell-driven lymphoid response that started to resolve by 21 days post final exposure. Discussion: C. neoformans remained in the lungs and exacerbated the pulmonary immune responses as expected following repeated exposure. The persistence of V. victoriae in the lung and strong lymphoid response following repeated exposure were unexpected given its lack of reported involvement in AAD. Given the abundance in indoor environments and industrial utilization of V. victoriae, these results highlight the importance to investigate the impact of frequently detected fungal organisms on the pulmonary response following inhalational exposure. Moreover, it is important to continue to address the knowledge gap involving Basidiomycota yeasts and their impact on AAD. Corrigendum: https://doi.org/10.3389/fcimb.2024.1381148: In the published article, there was an error in the author list, and author Karen C. Dannemiller was erroneously excluded. [Description provided by NIOSH]
• Subjects:
  Animals Asthma Asthma, Occupational Fungi Hypersensitivity Immune System Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Allergic Reactions; Respiratory Diseases; Yeasts; Animal Studies; Asthma; Pulmonary Effects; Immune Reaction; Fungal Infections; Fungi; Inhalation Studies; Author Keywords: Yeast; Fungi; Inflammation; Allergic Disease; Vishniacozyma Victoriae; Cryptococcus Neoformans; Exposure
• ISSN:
  2235-2988
• Document Type:
  Text
• Funding:
  Interagency Agreement
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  2 pdf pages
• NIOSHTIC Number:
  nn:20067045
• Citation:
  Front Cell Infect Microbiol 2023 Feb; 13:1067475
• Contact Point Address:
  Tara L. Croston, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, United States
• Email:
  xzu9@cdc.gov
• Federal Fiscal Year:
  2023
• Peer Reviewed:
  True
• Source Full Name:
  Frontiers in Cellular and Infection Microbiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a056183be88e278f8df68e84a27a61da8438f8f5080156ebedac21576807aadce5d3d0f2384099e941905f341cbe2ac04e1d45b03e6f941f74978dcf1437115b
• Download URL:
  https://stacks.cdc.gov/view/cdc/231606/cdc_231606_DS1.pdf
• File Type:
  [PDF - 237.98 KB ]