Respiratory System, Part Two: Allergy and Asthma

Details

• Personal Author:
  Alenius H ; Beezhold, Donald H. ; Shurin GV ; Shurin MR ; Shvedova AA
• Description:
  It is evident that inhalation of ENM can elicit asthma and allergy-like pulmonary inflammation in murine models. Although mechanisms are not completely known, it is likely that the ENMs induce sterile inflammation through damage-associated molecular patterns (DAMPS) and secretion of the IL-1 family members (including IL-33) and thereby play an important role in allergic inflammation. Evidence exits that rod-like multiwalled carbon nanotubes are especially adept at inducing innate immune-mediated asthma-like reactions. Not unexpectedly, airway exposure to ENPs also exacerbates 1h2 inflammation in mouse models suggesting that subjects with underlying allergies may be more susceptible to inhalation of ENP compared to healthy subjects. Importantly, new evidence demonstrates that airborne ENMs may also alter the functional activity of antigen-presenting cells, such as dendritic cells, in the lungs and systemically. In line with this, strong evidence exits that patients with bronchial asthma are highly sensitive to inhaled substances including particulate matter. Despite the growing evidence of the involvement of ENPs in inflammatory reactions, the mechanism by which nanostructures possibly modulate allergic responses are still poorly known, The evidence suggests that both innate and adaptive immune responses may be involved in the modulation of asthmatic reactions after exposure to ENMs. Understanding the interplay between sterile and allergen induced airway inflammation will be important in discerning the influence of nanoparticles on allergic disease. [Description provided by NIOSH]
• Subjects:
  Animals Asthma Environmental Exposure Hypersensitivity Immune System Laboratories Lung Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Allergic Disorders Allergic Reactions Allergies Allergy Author Keywords: Respiratory System Bronchial Asthma Carbon Nanotubes Chemokines Cytokines Exposure Levels Immune System Immune System Disorders Laboratory Animals Lung Function Lung Irritants Molecular Weight Nanoparticles Particulates Pulmonary System Disorders Respiratory System Disorders

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• ISBN:
  9780128091999
• Publisher:
  Academic Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  243-253
• NIOSHTIC Number:
  nn:20049817
• Citation:
  Adverse effects of engineered nanomaterials: exposure, toxicology, and impact on human health, 2nd edition. Fadeel B, Pietroiusti A, Shvedova AA, eds. San Diego, CA: Academic Press, 2017 Mar; :243-253
• Editor(s):
  Fadeel B; Pietroiusti A; Shvedova AA
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Respiratory system, part two: allergy and asthma
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b376c0a6464f7c2949196790fb5d819557c7040ae39c0d74bffd9e9221d88054dd5356077e6547e648b5150c297c1a2375bd86147aed27425a044de8f9dece24
• Download URL:
  https://stacks.cdc.gov/view/cdc/210442/cdc_210442_DS1.pdf
• File Type:
  [PDF - 1.09 MB ]